Condensed plasmid-liposome complex for transfection

Details Condensed plasmid-liposome complex for transfection Condensed plasmid-liposome complex for transfection

1998-09-11

2000-10-17

Schwartzman, Robert A.

Chemistry: molecular biology and microbiology

Vector, per se

424417, 424420, 4272313, 435 691, 536 231, C12N 1563, A01N 2526, C07H 2104, C12P 2102

Patent

active

061330264

ABSTRACT:
A plasmid-liposome composition for transfection of a cell is described. The composition includes plasmid molecules condensed with a polycationic condensing agent and cationic liposomes. Also disclosed is a method for preparing the plasmid-liposome complexes.

REFERENCES:
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Hong, K., et al., "Stabilization of cationic liposome-plasmid DNA complexes by polyamines and poly (ethylene glycol) -phospholipid conjugates for efficient in vivo gene delivery" FEBS Letters 400:233-237 (1997).

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