Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2008-01-29
2008-01-29
Anderson, Rebecca (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S427000
Reexamination Certificate
active
07323487
ABSTRACT:
A chemical compound of formula (I) wherein R1and R2are independently selected from hydrogen and alkyl; R3is alkyl; R4and R5are selected from hydrogen and alkyl; R6and R7are independently selected from hydrogen, halogen, hydroxyl, alkyl, aryl, amino, alkylamino, dialkylamino, alkoxy, aryloxy, alkylthio, alkylsulfoxyl, nitro, carbonitrile, carbo-alkoxy, carbo-aryloxy and carboxyl; and A is a 5- or 6-membered ring optionally containing one or more heteroatoms wherein the atoms of the ring A, other than the unsaturated carbon atoms of the phenyl ring to which the ring A is fused, are saturated or unsaturated, and pharmaceutically acceptable salts, addition compounds and prodrugs thereof; and the use thereof in therapy, particularly as an agonist or antagonist of a 5HT receptor, particularly a 5HT2creceptor, for instance in the treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders; diabetes insipidus, and sleep apnea, and particularly for the treatment of obesity.
REFERENCES:
patent: 2541211 (1951-02-01), Cusic et al.
patent: 2687414 (1954-08-01), Cusic
patent: 3142678 (1964-07-01), Rice et al.
patent: 3329571 (1967-07-01), Rice et al.
patent: 5494928 (1996-02-01), Bos
patent: 5561150 (1996-10-01), Wichmann
patent: 5633276 (1997-05-01), North et al.
patent: 5646173 (1997-07-01), Bos et al.
patent: 5755829 (1998-05-01), Terronova et al.
patent: 6433175 (2002-08-01), Adams et al.
patent: 6706750 (2004-03-01), Bentley et al.
patent: 930 988 (1955-07-01), None
patent: WO 95/17405 (1995-06-01), None
patent: WO 98/30548 (1998-07-01), None
patent: WO 98/56768 (1998-12-01), None
patent: WO 00/12475 (2000-03-01), None
patent: WO 00/12502 (2000-03-01), None
patent: WO 01/12603 (2001-02-01), None
Curr. Opin. Invest. Drugs (Apr. 1993), 2(4):317-362.
European J. Pharmacol. 359 (1998), 33-40.
Int. J. Fertility and Women's Medicine 42(2) 67-72.
Adams David Reginald
Davidson James Edward Paul
Hamlyn Richard John
Mansell Howard Langham
Roffey Jonathan Richard Anthony
Anderson Rebecca
Foley & Lardner LLP
Vernalis Research Limited
LandOfFree
Condensed indoline derivatives and their use as 5HT, in... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Condensed indoline derivatives and their use as 5HT, in..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Condensed indoline derivatives and their use as 5HT, in... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2794077