Condensed indole derivatives as 5HT.sub.4 -receptor antagonists

Details Condensed indole derivatives as 5HT.sub.4 -receptor antagonists Condensed indole derivatives as 5HT.sub.4 -receptor antagonists

1995-06-02

1998-12-22

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514211, 514214, 514220, 5142246, 514248, 514294, 514321, 514322, 514323, 514366, 514375, 514393, 540547, 540561, 540586, 544 32, 544 89, 544252, 546 94, 546198, 546199, 546200, 546150, 546217, 5463024, 546428, H61K 31535, C07D49804

Patent

active

058520147

ABSTRACT:
Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## and their use as pharmaceuticals in the treatment of gastrointestinal disorders, cardiovascular disorders and CNS disorders.

REFERENCES:
patent: 4314058 (1982-02-01), Hayami et al.
patent: 5001133 (1991-03-01), Richardson et al.
patent: 5705498 (1998-01-01), Gaster et al.
Dumuis, et al., "The gastrointestinal prokinetic benzamide derivatives are agonists at the non-classical 5-HT receptor (5-HT4) positively coupled to adenylate cyclase neurons", Archives of Pharmacology, 340:pp. 403-410 (1989).
Dumius, et al., "A-5HT receptor in central nervous system positively coupled with adenylate cyclase, is antagonized by ICS 205 930", European Journal of Pharmacology, 146:pp. 187-188 (1988).
A. J. Kaumann, "Piglet sinoatrial 5-HT receptors resemble human atrial 5-HT.sub.4 -like receptors", Archives of Pharmacology, 342, pp. 619-622 (1990).
Dumius et al., "A Nonclassical 5-Hydroxytruptamine Receptor Positively Coupled with Adenylate Cyclase in the Central Nervous System", Mol. Pharmacology, 34, pp. 880-887 (1988).
Welch et al., "Biochemical Comparison of Migraine and Stroke", Headache, 16, pp. 160-167 (1976).
Saxena, P.R. Pharmacology and Therapeutics, vol. 66, pp. 339-368 (1995).
Dhasmana, K.M., et al Life Sciences, vol. 53, pp. 1651-1661 (1993).

Affiliated with

Also associated with

Rating

Condensed indole derivatives as 5HT.sub.4 -receptor antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Condensed indole derivatives as 5HT.sub.4 -receptor antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Condensed indole derivatives as 5HT.sub.4 -receptor antagonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2047896