Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2003-07-11
2009-06-02
Saeed, Kamal A (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S360500
Reexamination Certificate
active
07541378
ABSTRACT:
Bicyclo-pyrazole compound of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, processes for their preparation, combinatorial libraries comprising a plurality of them and pharmaceutical compositions thereof, are herewith disclosed: the compounds of the invention are useful, in therapy, as protein kinase inhibitors, for instance in the treatment of cancer.
REFERENCES:
patent: 2005/0187209 (2005-08-01), Fancelli et al.
(Mar. 19, 2004 Protein Kinase Inhibitors: Insights into Drug Define from Structure.
Antonio R. Damasio, Cecil Textbook of Medicine, 1996, W.B. Saunders Company, 20th Edition, vol. 2, pp. 1992-1996.
Robert B. Layzer, Cecil Textbook of Medicine, 1996, W.B. Saunders Company, 20th Edition, vol. 2, pp. 2050-2057.
FDA mulls drug to slow late-stage Alzheimer's [online], [retrieved on Sep. 23, 2003], Retrieved from the Internet, URL; http://www.cnn.com/2003/HEALTH/conditions/O9/24/alzheimers.drug.ap/index.html, pp. 1 and 2.
Joel R. Huff, HIV Protease: A Novel Chemotherapeutic Target for AIDS, 1991, Journal of Medicinal Chemistry, vol. 34, No. 8, pp. 2305-2314.
Golub et al., Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring, 1999, Science, vol. 286, pp. 531-537.
Lala et al., Role of nitric oxide in tumor progression: Lessons from experimental tumors, 1998, Cancer and Metastasis Reviews, 17(1), pp. 91-106.
Elnagdi M.H. et al., “The Reaction of Phenacyl Malononitrile with Hydrazines: Synthesis of New Pyridzainones and Pyrazolo[1,5-α] Pyrimidines”,Gazzetta Chimica Italiana127:791-794 (1997), XP009018422.
Sherif S.M. et al., “Syntheses with Heterocyclic β-Enaminonitriles: An Expeditious Synthetic Approach to Polyfunctionally Substituted 5-Phenyl-Suflonylthiophenes and their Fused Derivatives”,Monatshefte für Chemie128:687-696 (1997), XP009018423.
Abdel Fattah Ali Harb, “Nitriles in Heterocyclic Synthesis: Novel Routus to Cyclopentenothienopyridines, Cyclopentenothieno-Pyrimidenes and Cyclopentenopyrrolopyrazoles”,Egyptian Journal of Pharmaceutical Sciences 33(1-2):283-292 (1992).
Abdelrazek F.M. et al., “Nitriles in Heterocyclic Synthesis. A Novel Synthesis of 4-Phenacylpyrazole and Pyrrolo[2,3-c]Pyrazole”,Synthesis 74-75(1986), XP-001155261.
Bindi Simona
Fancelli Daniele
Pittala′ Valeria
Tonani Roberto
Varasi Mario
Bianchi Kristin
Pfizer Italia S.r.l.
Saeed Kamal A
Scully , Scott, Murphy & Presser, P.C.
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