Condensed heterocyclic compounds useful for inhibiting acyl-CoA

Details Condensed heterocyclic compounds useful for inhibiting acyl-CoA Condensed heterocyclic compounds useful for inhibiting acyl-CoA

1993-12-14

1996-02-20

Haley, Jacqueline

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514469, 549467, 549469, A61K 3134, C07D30782

Patent

active

054929296

ABSTRACT:
Novel compound represented by the formula: ##STR1## wherein ring A, ring B and ring C each stands for an optionally substituted benzene ring; X stands for --NR-- wherein R stands for hydrogen atom or an optionally substituted hydrocarbon group, --O-- or --S--; Y stands for --(CH.sub.2)n-- wherein n denotes 1 or 2 or --NH--; and R.sup.a stands for a hydrogen atom or an optionally substituted hydrocarbon group, provided that when ring C is unsubstituted or substituted only at para-position, ring B is substituted at least at ortho-position or a salt thereof which have an excellent acyl-CoA: cholesterol acyltransferase inhibiting action and cholesterol-lowering activity, their production and medicinal use.

REFERENCES:
patent: 3944672 (1976-03-01), Steinman
patent: 4054585 (1977-10-01), Felauer et al.
patent: 4113731 (1978-09-01), Winters et al.
Winters et al. I1 Farmaco--Ed. Sc. vol. 34(6) (1978), "Synthesis and Biological Activities of Some Indolo [2,3-c] Isoquinoline Derivatives". Pp. 507-517.
Chemical Abstracts vol. 117, No. 48431C, 1992.
Chatterjea et al. J. Indian Chem. Soc. vol. LIII (1976) 295-299, "Syntheses of Furano Compounds".
Chatterjae et al. J. Indian Chem. Soc. vol. 33(5) (1956), 339-345, "Experiments on the Syntheses of Furano Compounds."

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