Condensed heterocyclic compounds, their production and use

Details Condensed heterocyclic compounds, their production and use Condensed heterocyclic compounds, their production and use

1995-04-25

1997-03-04

McKane, Joseph

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514399, 5142335, 514414, 514459, 514255, 514320, 514212, 514213, 514444, 514337, 514316, 514323, 514367, 5483114, 548454, 548159, 546201, 546150, 546187, 5462817, 5462827, 546 17, 546196, 5462727, 5462771, 5462764, 544364, 544376, 544151, 544368, 540594, 540596, 549406, 549 60, A61K 3144, C07D40106

Patent

active

056079397

ABSTRACT:
The compound ##STR1## wherein ring A represents a benzene ring; Ar represents an aromatic group; R.sup.1 and R.sup.2 independently represent hydrogen, acyl or hydrocarbon group or R.sup.1 and R.sup.2 taken together with the adjacent nitrogen atom represent a nitrogen-containing heterocyclic group; m represents an integer of 1 to 6; n represents an integer of 2 to 3; ----- represents a single bond or a double bond; X stands for --O-- or --NR.sup.3 -- in which R.sup.3 represents hydrogen, acyl or hydrocarbon group where ----- is a single bond or .dbd.N-- where ----- is a double bond has excellent GnRH receptor antagonizing activity, calcium antagonizing and monoamine-uptake inhibiting activities and and value as a prophylactic/therapeutic drug for sex hormone-dependent diseases and for central nervous system diseases.

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patent: 4247553 (1981-01-01), McCall
patent: 4650884 (1987-03-01), Bogeso
McCall, J. M., 1-(Alkylamino)isochromans: Hypotensives with Preipheral and Central Activities, J. Med. Chem., 25, pp. 75-81 1982.

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