Condensed heterocyclic compounds, their production and use

Details Condensed heterocyclic compounds, their production and use Condensed heterocyclic compounds, their production and use

1995-11-08

1999-07-27

Stockton, Laura L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549 57, 549 58, A61K 3138, C07D33358, C07D33366

Patent

active

059291079

ABSTRACT:
Novel compound represented by the formula: ##STR1## wherein ring A, ring B and ring C each stands for an optionally substituted benzene ring; X stands for --NR-- wherein R stands for hydrogen atom or an optionally substituted hydrocarbon group, --O-- or --S--; Y stands for --(CH.sub.2)n-- wherein n denotes 1 or 2 or --NH--; and R.sup.a stands for a hydrogen atom or an optionally substituted hydrocarbon group, provided that when ring C is unsubstituted or substituted only at para-position, ring B is substituted at least at ortho-position or a salt thereof which have an excellent acyl-CoA: cholesterol acyltransferase inhibiting action and cholesterol-lowering activity, their production and medicinal use.

REFERENCES:
patent: 3944672 (1976-03-01), Steinman
patent: 4054585 (1977-10-01), Felauer et al.
patent: 4113731 (1978-09-01), Winters et al.
patent: 5464863 (1995-11-01), Nagamine et al.
Isoquinoline Derivatives, I1 Farmaco--Ed. Sc. vol. 34(6), 1978, pp. 507-517.
Chemical Abstracts vol. 117, No. 48431C, 1992.
Chatterjea et al., "Synthesis of Furano Compounds", J. Indian Chem. Soc., vol. LIII (1976), pp. 295-299.
Chatterjea et al., "Experiments on the Synthesis of Furano Compounds", J. Indian Chem. Soc., vol. 33(5), 1956, pp. 339-345.

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