Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1989-07-10
1991-08-06
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142282, 514255, 514431, 514432, 514434, 514439, 514440, 514443, 544 62, 544145, 544146, 544377, 549 9, 549 10, 549 11, 549 15, 549 23, 549 49, 549 53, 549 57, 549 58, A61K 31385, A61K 3138, C07D33708, C07D33908
Patent
active
050378252
ABSTRACT:
The invention relates to compounds of the formula ##STR1## wherein R.sup.1 is hydrogen, acyl, lower-alkyl or --CHO, --CH.sub.2 OR.sup.10, --COR.sup.7 or OR.sup.13 ; R.sup.2, R.sup.3 and R.sup.4 are, independently, hydrogen, lower-alkyl, lower-alkoxy or halogen; R.sup.5 and R.sup.6 are, independently, hydrogen or lower-alkyl; R.sup.7 is hydroxy, lower-alkoxy or NR.sup.8 R.sup.9 ; R.sup.8 and R.sup.9 are, independently, hydrogen or lower-alkyl; X and Y are, independently, >CR.sup.14 R.sup.15, --O--, --S--, >SO, >SO.sub.2 or >NR.sup.18 ; R.sup.10 and R.sup.18 are, independently, hydrogen, lower-alkyl or acyl; M is --C(R.sup.11).dbd.C(R.sup.12)--, --CONH-- or --NH--CO--; R.sup.11, R.sup.12, R.sup.14 and R.sup.15 are, independently, hydrogen or lower-alkyl, R.sup.13 is hydrogen, lower-alkoxycarbonyl or lower- alkyl, which can be substituted by amino, mono-alkylamino, di-alkylamino, morpholino, thiomorpholino or piperazino; and n is 1, 2, 3 or 4; with the proviso that at least one of X and Y comprises a hetero atom and n is 1, 3 or 4 when X contains a hetero atom, Y is >C(CH.sub.3).sub.2 and R.sup.1 is lower-alkyl or --CH.sub.2 OR.sup.10 or --COR.sup.7,
or a salt of a compound of formula I, when R.sup.1 is carboxy.
The compounds of formula I are useful in the treatment of prophylaxis of neoplasms, dermatoses and ageing of the skin.
REFERENCES:
patent: 3635941 (1972-01-01), Weaver et al.
patent: 4678793 (1987-07-01), Klaus et al.
patent: 4808597 (1989-02-01), Hoffman et al.
patent: 4826984 (1989-05-01), Berlin et al.
Berlin et al., Chem. Abstracts, vol. 111, No. 19; 173986q, (1989).
Hirose et al., Chem. Abstracts, vol. 105, No. 26; 235743v, (1986).
Chemical Abstracts, vol. 70, p. 299, #77526d (1969).
Heterocycl. Chem. 8(4), pp. 681-684 (1971).
Tetrahedron Letters, vol. 29, No. 22, pp. 2241-2744 (1988).
Tetrahedron, vol. 31, pp. 449-454 (1975).
Chemical Abstracts, vol. 83, p. 574, #97160b (1975).
Chemical Abstracts, vol. 84, p. 406, #7377c (1976).
Chemical Abstracts, vol. 84, p. 406, #150546f (1976).
J. Org. Chem., No. 9, pp. 1242-1247 (1974).
Klaus Michael
Mohr Peter
Weiss Ekkehard
Gould George M.
Hoffmann-La Roche Inc.
Isgro William G.
Leon Bernard S.
Richter Johann
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