Condensed furan compounds

Details Condensed furan compounds Condensed furan compounds

2009-01-29

2010-06-15

Anderson, Rebecca L (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S115000

Reexamination Certificate

active

07737161

ABSTRACT:
The present invention provides a condensed furan compound of the formula (I):wherein Ring X is benzene, pyridine, or the like; Y is an optionally substituted amino, an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted saturated heterocyclic group, an optionally substituted unsaturated heterocyclic group; A is a single bond, lower alkylene, lower alkenylidene, lower alkenylene or an oxygen atom; R3is hydrogen or the like; and, R4is hydrogen, or the like, or pharmaceutically acceptable salts thereof, which is useful as a medicament, particularly, as an activated blood coagulation factor X inhibitor.

REFERENCES:
patent: 5753670 (1998-05-01), Ono et al.
patent: 6143761 (2000-11-01), Lochead et al.
patent: 2003/0203909 (2003-10-01), Ushio et al.
patent: 1 277 738 (2003-01-01), None
patent: WO-94/17075 (1994-08-01), None
patent: WO-95/33720 (1995-12-01), None
patent: WO-96/22992 (1996-08-01), None
patent: WO-99/42439 (1999-08-01), None
patent: WO-01/83456 (2001-08-01), None
patent: WO-02/12189 (2002-02-01), None
patent: WO-03/082847 (2003-10-01), None
patent: WO-2004/012671 (2004-02-01), None
patent: WO-2005/039506 (2005-05-01), None
Harwalkar, G.S. et al., “Synthesis and Reactions of 2-Substituted-4H-Benzofuro[3,2-d]-m-Oxazin-4-Ones,” Indian Journal of Heterocyclic Chemistry, vol. 3, Apr.-Jun. 1994, pp. 247-252.
Sogorinsho 41:2913-2918, 1992 and English short summary.
Freedman, Michal D., “Oral Anticoagulants: Pharmacodynamics, Clinical Indications and Adverse Effects,” J. Clin. Pharmacol. 1992;32:196-209.
Hirsh, Jack, “Oral Anticoagulant Drugs,” The New England Journal of Medicine, vol. 324, No. 26, Jun. 1991; pp. 1865-1875.
Sixma, Jan J. et al., “The Ideal Anti-Thrombotic Drug,” Thrombosis Research, 1992, vol. 68, pp. 507-512.
Matsuo, O. ed., “t-PA and Pro-UK,” Gakusaikikaku, 1986, pp. 5-40.
Kaiser, Brigitte et al., “Pharmacological Characterization of a New Highly Effective Synthetic Thrombin Inhibitor,” Biomed. Biochim. Acta 44 (1985) 7/8, pp. 1201-1210.
Gewald et al., “Journal F. prakt. Chem. Band” vol. 318 No. 2, 1976, XP009019038, pp. 313-320.
Attia et al., “Synthesis of some furopyridine derivatives” XP002446231, database accession, No. 1989: 75349.
Wagner et al., pp. 250-253, XP002446225, (1993) Pharmazie, vol. 48, No. 4.
Narsaiah et al. “Journal of Fluorine Chemistry ”, vol. 69, 1994, pp. 139-143, XP002446226.
Khattab et al., “Sulfur Letters” vol. 19, No. 1, 1995 pp. 23-28, XP009054957.
Dunn et al.,J. prakt. Chem., vol. 338, pp. 663-666, 1996, XP002446227.
Srinivas et al., “A facile synthesis of 4-oxo-1,2,3,4- tetrahydropy ridofuropyridines” XP-002446232, Database accession No. 2003: 243614.
Mohamed et al., “Journal of the Chemical Society of Pakistan” ISSN: 0253-5106, 1985, XP-002446233.
Chandra Sheker Reddy et al., “Journal of Flourine Chemistry” vol. 74, 1995, pp. 1-7, XP004020503.
Wagner et al., pp. 213-214, XP002446224, (1990) Pharmazie, vol. 45, No. 3.
A. Attia et al, Egypt. J. Chem. vol. 28, No. 5, pp. 427-432 (1985).
K Srinivas et al, Indian Journal of Chemistry vol. 42B, Mar. 2003, pp. 605-610.
Tidwell et al., Thrombosis Research, 19; 339-349, 1980.

Affiliated with

Also associated with

Rating

Condensed furan compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Condensed furan compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Condensed furan compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4183943