Condensed diazepinones, processes for preparing them and pharmac

Details Condensed diazepinones, processes for preparing them and pharmac Condensed diazepinones, processes for preparing them and pharmac

1989-05-30

1991-04-09

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540495, A61K 3155, C07D52100

Patent

active

050065220

ABSTRACT:
Novel condensed diazepinone of general formula I are described, ##STR1## wherein B represents one of the divalent groups ##STR2## and X.sup.1, X.sup.2, A.sup.1, A.sup.2 and R.sup.1 to R.sup.10 are as defined in herein useful as vagal pacemakers for treating bradycardia and bradyarrhythmia. The novel diazepinones also have spasmolytic properties on peripheral organs, antiemetic properties and are capable of promoting cerebral blood flow.

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Beilstein, "Handbuch der Organischen Chemie", Band 4 E III, p. 306, (1927).

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