Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-07-11
2006-07-11
Coleman, Brenda (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C540S593000
Reexamination Certificate
active
07074781
ABSTRACT:
This invention provides novel compounds according to general formula (1) wherein A is a bicyclic or tricyclic azepine derivative, V1and V2are both H, OMe or F, or one of V1and V2is Br, Cl, F, OH, OMe, OBn, OPh, O-acyl, N3, NH2, NHBn or NH-acyl and the other is H, or V1and V2together are ═O, —O(CH2)pO— or —S(CH2)pS—; W1is either O or S; X1and X2are both H, or together are ═O or ═S; Y is OR5or NR6R7; R1, R2, R3and R4are independently selected from H, lower alkyl, lower alkyloxy, F, Cl and Br; R5is selected from H and lower alkyl; R6and R7are independently selected from H and lower alkyl, or together are —(CH2)n—; n=3, 4, 5, 6; and p is 2 or 3. The compounds are agonists at the vasopressin V2 receptor and are useful as antidiuretics and procoagulants. The invention further comprises pharmaceutical compositions incorporating these vasopressin agonists, which compositions are particularly useful in the treatment of central diabetes insipidus, nocturnal enuresis and nocturia.
REFERENCES:
patent: 5753644 (1998-05-01), Ogawa et al.
patent: 0 514 667 (1992-11-01), None
patent: WO 94/12476 (1994-06-01), None
patent: WO 94/20473 (1994-09-01), None
Patent Abstracts of Japan vol. 1999, No. 08, Jun. 30, 1999 & JP 11 060488 A (Otuka Pharmaceutical Co., Ltd.), Mar. 2, 1999 (Abstract).
Patent Abstracts of Japan vol. 018, No. 140, Mar. 8, 1994 & JP 05 320135 A (Yamanouchi Pharmaceutical Co., Ltd.), Dec. 3, 1993 (Abstract).
Ashworth Doreen Mary
Franklin Richard Jeremy
Hudson Peter
Pitt Gary Robert William
Yea Christopher Martyn
Coleman Brenda
Ferring BV
Foley & Lardner LLP
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