Condensed 4,5,6,7-tetrahydrobenzo[C]thiophenes as enhancer for c

Details Condensed 4,5,6,7-tetrahydrobenzo[C]thiophenes as enhancer for c Condensed 4,5,6,7-tetrahydrobenzo[C]thiophenes as enhancer for c

1999-02-19

2000-05-23

Stockton, Laura L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514 81, 514366, 5462701, 548113, 548151, A61K 314439, A61K 31429, C07D51304

Patent

active

060666587

ABSTRACT:
A compound represented by the formula: ##STR1## wherein X represents a sulfur atom or an oxygen atom; Y represents an optionally oxidized sulfur atom or an oxygen atom; Z represents a bond or a divalent hydrocarbon group; R.sup.1 represents an optionally substituted hydrocarbon group; R.sup.2 represents an optionally amidated or esterified carboxyl group; ring A represents an optionally substituted aromatic 5-membered heterocyclic ring; or a salt thereof. A compound of the above formula possesses cell differentiation inducing factor action-enhancing activity and anti-matrix metalloprotease activity and that is useful in the prevention and treatment of bone diseases such as osteoporosis, bone fractures, osteoarthritis and rheumatoid arthritis, arteriosclerosis, cancer metastasis, and diseases based on nerve degeneration.

REFERENCES:
Augustin et al., J. Prakt, Chem., vol. 321, No. 2, 1979, pp. 215-225.
Prim et al., Liebigs Ann., No. 2, 1996, pp. 239-245.
Maybridge Chemical Co., Ltd. Catalogue, Oct. 1991, pp. 1-6.
van Rhee et al., J. Med. Chem. 1996, vol. 39, No. 2, pp. 389-406.
Prim et al., Synthetic Communications, 25(16), pp. 2449-2455 (1995).

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