Surgery – Diagnostic testing – Respiratory
Patent
1996-03-28
2000-03-07
Nasser, Robert L.
Surgery
Diagnostic testing
Respiratory
73 233, 422 84, A61B 500
Patent
active
060333685
ABSTRACT:
Disclosed is a device for determination of the content of higher oxides of nitrogen in exhaled breath condensate which comprises a conduit having an exhalate condensing portion with an inlet and an outlet (the inlet canbe configured to fit with a mechanical respirator or, for direct use by the patient, an inlet assembly providing one-way ingress of ambient atmosphere to the device can be associated with the inlet of the conduit exhalate condensing portion); a coolant jacket coaxially surrounding said exhalate condensing portion; a gas release port; and, in enclosed fluid communication with said conduit exhalate condensing portion outlet, a sample assay assembly comprising (i) a translucent analysis chamber attached to the outlet to receive condensate fluid and having a reagent entry port, (ii) a reagent chamber in enclosed fluid communication with the reagent entry port and (iii) a pliable element connecting the outlet and the analysis chamber and forming a portion of the reagent chamber such that flexion of the pliable element closes communication between the outlet and the analysis chamber and contracts the reagent chamber so as to deliver to the analysis chamber controlled amounts of condensate and reagent. The device is disposable and inexpensive, and is used to collect human exhalate for calorimetric assay of liquid and gas phase nitrogen oxides to assist in evaluation of airway inflammation.
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Hunt et al, "Condensed Expirate Nitrite As A Home Marker For Acute Asthma," The Lancet, 346:1235-1236 (Nov. 4, 1995).
Gaston, IV Benjamin M.
Hunt John F.
Nasser Robert L.
NitroMed Inc.
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