Concentrated stabilized microbubble-type ultrasonic imaging agen

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent

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514945, 12866001, A61K 4900

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active

048448826

ABSTRACT:
A microbubble-type ultrasonic imaging agent is provided comprising a parenterally-administerable aqueous medium containing a dispersion of microspheres predominantly of diameters less than 10 microns, wherein the microspheres consist of gas microbubbles encapsulated with water-insolubilized biocompatible material. The imaging agent is characterized by having a concentration of greater than 100.times.10.sup.6 microspheres per milliliter, and a stability such that this concentration is maintained for over 4 weeks at a temperature of 20.degree. to 25.degree. C.

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Feinstein et al., (1984), J. Am. Coll. Cardio., 3:14-20.
Keller et al., (1987), Amer. Heart J., 114:570-575.

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