Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1987-12-29
1989-07-04
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
514945, 12866001, A61K 4900
Patent
active
048448826
ABSTRACT:
A microbubble-type ultrasonic imaging agent is provided comprising a parenterally-administerable aqueous medium containing a dispersion of microspheres predominantly of diameters less than 10 microns, wherein the microspheres consist of gas microbubbles encapsulated with water-insolubilized biocompatible material. The imaging agent is characterized by having a concentration of greater than 100.times.10.sup.6 microspheres per milliliter, and a stability such that this concentration is maintained for over 4 weeks at a temperature of 20.degree. to 25.degree. C.
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Westkaemper Peter J.
Widder Kenneth J.
Henley III Raymond J.
Molecular Biosystems, Inc.
Robinson Douglas W.
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