Concentrate of thrombin coagulable proteins, the method of obtai

Details Concentrate of thrombin coagulable proteins, the method of obtai Concentrate of thrombin coagulable proteins, the method of obtai

1992-04-24

1993-11-09

Schain, Howard E.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530381, A61K 3516, A61K 914

Patent

active

052604209

ABSTRACT:
The invention provides a thrombin coagulable protein concentrate,, the preparation thereof and the therapeutic use thereof. This concentrate has a fibrinogen content greater than 70% and a sufficient amount of endogenous Factor XIII. It may be solubilized at ambient temperature. Its preparation comprises at least one cold precipitation step with dilute ethanol and uses total plasma as a starting product. The concentrate of the invention makes it possible more particularly to obtain an injectable fibrinogen and a biological glue of high quality.

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Quinn et al. (1983), Abstract, J. Pharm. Sci. 72, 1472.
Biological Abstracts, vol. 77, No. 7, 1984, resume No. 49207, Philadelphia, U.S., M. G. Ikossi-O'Connor et al: "The Role of Fibrin Adhesive in Vascular Surgery".

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