Concentrate of a factor VIII:C-containing von Willebrand...

Details Concentrate of a factor VIII:C-containing von Willebrand... Concentrate of a factor VIII:C-containing von Willebrand...

2003-09-26

2009-12-01

Kam, Chih-Min (Department: 1656)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S002600, C530S350000, C530S383000

Reexamination Certificate

active

07625866

ABSTRACT:
The invention relates to a concentrate and a process for producing a factor VIII:C-containing von Willebrand factor by fractional precipitation from a liquid comprising factor VIII:C and von Willebrand factor, resulting in an increased content of high molecular weight multimers of von Willebrand factor and a ratio of the vWF:RCoF activity to vWF:Ag of greater than 1.

REFERENCES:
patent: 5288853 (1994-02-01), Bhattacharva et al.
patent: 6228613 (2001-05-01), Fischer et al.
patent: 6239261 (2001-05-01), Heimburger et al.
patent: 6579723 (2003-06-01), Mitterer et al.
patent: 0 705 846 (1995-09-01), None
patent: WO 98/38218 (1998-09-01), None
Heimburger et al., Drug Res. 31(1), Nr. 4 (1981), Faktor-Konzentrat, hochgereinigt und in Losung erhitzt, pp. 619-622.
German Translation of Heimburger et al., pp. 1-14.
Von N. Heimburger et al., “Factor VII-Konzentrat, hochgereinigt und in Lösung erhitzt”, Arzneim-Forsch./Drug Res. 31 (I), Nr. 4, pp. 619-622, (1981).
Mannucci, P. M. et al., “Multicenter Comparison of von Willebrand Factor Multimer Sizing Techniques,”Thrombosis and Haemostasis, 54(4): 873-876 (1985).
Lombardi, R. et al., “Electroblot and Immunoperoxidase Staining for Rapid Screening of the Abnormalities of the Multimeric Structure of von Willebrand Factor in von Willebrand's Disease,”Thrombosis and Haemostasis, 55(2): 246-249 (1986).
Baillod, P. et al., “Multimeric Analysis of von Willebrand Factor by Vertical Sodium Dodecyl Sulphate Agarose Gel Electrophoresis, Vacuum Blotting Technology and Sensitive Visualization by Alkaline Phosphatase Anti-Alkaline Phosphatase Complex,”Thrombosis Research, 66: 745-755 (1992).
Girma, J.P. et al., “Structure-Function Relationship of Human Von Willebrand Factor,”Blood, 70(3): 605-611 (1987).
Hamer, R. J., “Factor VIII Binds to von Willebrand Factor Via Its Mr-80 000 Light Chain,”Eur. J. Biochem., 166: 37-43 (1987).
Cornu, P. et al., “Transfusion Studies in von Willebrand's Disease: Effect on Bleeding Time and Factor VIII,”Brit. J. Haemat, 9: 189-202 (1963).
Weiss, H. J. et al., “Stabilization of Factor VIII in Plasma by the von Willebrand Factor,”The Journal of Clinical Investigation, 60: 390-404 (1977).
Jaffe, E. A. et al., “Synthesis of von Willebrand Factor by Cultured Human Endothelial Cells,”Proc. Nat. Acad. Sci, 71(5): 1906-1909 (1974).
Nachman, R. et al., “Synthesis of Factor VIII Antigen by Cultured Guinea Pig Megakaryocytes,”The Journal of Clinical Investigation, 60: 914-921 (1977).
Scott, J. P. et al., “Therapy of von Willebrand Disease,”Seminars in Thrombosis and Hemostasis, 19(1): 37-47 (1993).
Perret, B.A. et al., “Isolation of Small Molecular Forms of Factor VIII/von Willebrand Factor from Plasma,”Haemostasis, 14: 289-295 (1984).
Kasper, C.K. et.al.; “A More Uniform Measurement of Factor VIII Inhibitors,”Thrombos. Diathes. Haemorrh., 34: 869-872 (1975).
Behrmann, M. et al., “Von Willebrand Factor Modulates Factor VIII Immunogenicity: Comparative Study of Different Factor VIII Concentrates in a Haemophilia A Mouse Model,”Thromb Haemost, 88: 221-229 (2002).

Affiliated with

Also associated with

Rating

Concentrate of a factor VIII:C-containing von Willebrand... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Concentrate of a factor VIII:C-containing von Willebrand..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Concentrate of a factor VIII:C-containing von Willebrand... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4110920