Concanavalin a binding proteins and a 76kD chondrocyte membrane

Details Concanavalin a binding proteins and a 76kD chondrocyte membrane Concanavalin a binding proteins and a 76kD chondrocyte membrane

1994-07-21

1997-03-04

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 8, 514 15, 530395, 530396, 530412, 530413, 530427, 530840, 435183, 435207, A61K 3800, C07K 100, C12N 900

Patent

active

056079206

ABSTRACT:
The invention is directed to purified and isolated concanavalin A-binding proteins from chondrocytes that are not present in dedifferentiated cells from chondrocytes. The invention is also directed to a purified and isolated chondrocyte membrane protein, (CMP), which is a concanavalin A-binding protein, with a molecular weight of about 76 kD in SDS-PAGE. After treatment with endoglycosidase, CMP has an apparent molecular weight of about 67 kD. The N-terminal amino acid sequence and several internal amino acid sequences are given for CMP. These proteins can be used in assays, methods, or treatments involving differentiation of chondrocytes and the control of cartilaginous osteogenesis.

REFERENCES:
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