Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Biological or biochemical
Reexamination Certificate
2011-03-08
2011-03-08
Skowronek, Karlheinz R (Department: 1631)
Data processing: measuring, calibrating, or testing
Measurement system in a specific environment
Biological or biochemical
C977S792000
Reexamination Certificate
active
07904250
ABSTRACT:
The present invention is a method to assist in the identification of single nucleotide polymorphisms (SNP) from microarray hybridization data. Data from hybridization protocols run on microarrays often have variations in the data resulting from variations in hybridization conditions and efficiencies and variations in optical intensities. An algorithm is described to screen the results to identify those data points most likely to be real SNPs as opposed to variations in the hybridization or sensing data.
REFERENCES:
patent: 5143854 (1992-09-01), Pirrung et al.
patent: 6375903 (2002-04-01), Cerrina et al.
Domeniconi et al. (Proceedings of the Eighteenth International Conference on Machine Learning, p. 98-105, 2001).
Wang et al. (Science, vol. 280, p. 1078-1082, May 15, 1998).
Hacia et al., “Detection of heterozygous mutations in BCRA1 using high density oligo nucleotide arrays and two-color fluorescence”, Nature, vol. 14, p. 441-447, 1996.
Kozal et al., “Extensive polymorphisms observed in HIV-1 Clade-B protease gene using high-density oligonucleotide arrays”, Nature Medicine, vol. 2, No. 7, 753-759, Jul. 1996.
Chee et al., “Accessing Genetic Information with High-Density DNA Arrays”, Science, vol. 274, No. 5287, p. 610-614, Oct. 25, 1996.
Cutler, D.J., et al., “High-Throughput Variation Detection and Genotyping Using Microarrays,” Genome Research 11:1913-1925 (2001).
Hirschhorn, J.N., et al., “SBE-TAGS: An array-based method for efficient single-nucleotide polymorphism genotyping,” PNAS 97:12164-12169 (2000).
Molla, M., et al., “A Self-Tuning Method for One-Chip SNP . . . ,” The Proceedings of the IEEE Conference on Computational Systems Bioinformatics (CSB 2004).
Nuwaysir, E.F., et al., “Gene Expression Analysis Using Oligonucleotide Arrays Produced by Maskless Photolithography,” Genome Research 12:1749-1755 (2002).
Ruan, Y., et al., “Comparative full-length genome sequence analysis of 14 SARS coronavirus isolates and common mutations . . . ,” The Lancet 361:1779-1785 (2003).
Singh-Gasson, S., et al., “Maskless fabrication of light-directed oligonucleotide microarrays using a digital micromirror array,” Nature Biology 17:974-978 (1999).
Wang, D.G., et al., “Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome,” Science 280:1077-1082 (1998).
Albert Thomas
Molla Michael
Richmond Todd
Smith Steven
Quarles & Brady LLP
Roche Nimblegen, Inc.
Skowronek Karlheinz R
LandOfFree
Computer software to assist in identifying SNPS with... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Computer software to assist in identifying SNPS with..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Computer software to assist in identifying SNPS with... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2708976