Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Biological or biochemical
Reexamination Certificate
2006-02-07
2006-02-07
Brusca, John S. (Department: 1631)
Data processing: measuring, calibrating, or testing
Measurement system in a specific environment
Biological or biochemical
C435S006120, C365S094000
Reexamination Certificate
active
06996475
ABSTRACT:
Methods and computer software products are provided for analyzing gene expression data. In one embodiment, multiple probes are used to detect a single transcript. The hybridization intensities of each probe is adjusted by dividing the intensities by the affinities of the probes. The minimal adjusted hybridization intensity may be used as the measurement of the gene expression.
REFERENCES:
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Steven R. Gullans (2000), “Of Microarrays and Meandering Data Points”, Nature Genetics, vol. 26, No. 1, pp. 4-5, http://www.nature.com, Aug. 26, 2002.
Stefanie Fuhrman, et al., “The Application of Shannon Entropy in the Identification of Putative Drug Targets”, BioSystems 55 (2000), Neurobiology Department, Incyte Pharaceuticals Inc., 3174 Porter Drive, Palo Alto, CA 94304, USA, pps. 5-14.
George C. Tseng, et al., “Issues in cDNA Microarray Analysis: Quality Filtering, Channel Normalization, Models of Variations and Assessment of Gene Effects”, Nucleic Acids Research 2001, vol. 29, No. 12, 2549-2557, © 2001 Oxford University Press.
Johannes Schuchardt, et al., “Normalization Strategies for cDNAS Microarrays”, Nucleic Acids Research, 2000, vol. 28, No. 10 E47-e47, © 2000 Oxford University Press.
Affymatrix, Inc
Brusca John S.
McGarrigle Philip L.
Zhou Wei
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