Computer-directed assembly of a polynucleotide encoding a...

Data processing: database and file management or data structures – Database and file access – Preparing data for information retrieval

Reexamination Certificate

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C435S006120, C536S023100, C702S020000, C703S011000, C706S013000

Reexamination Certificate

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07966338

ABSTRACT:
The present invention outlines a novel approach to utilizing the results of genomic sequence information by computer-directed polynucleotide assembly based upon information available in databases such as the human genome database. Specifically, the present invention may be used to select, synthesize and assemble a novel, synthetic target polynucleotide sequence encoding a target polypeptide. The target polynucleotide may encode a target polypeptide that exhibits enhanced or altered biological activity as compared to a model polypeptide encoded by a natural (wild-type) or model polynucleotide sequence.

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