Computer-controlled bioreactor system for enzymatic synthesis of

Details Computer-controlled bioreactor system for enzymatic synthesis of Computer-controlled bioreactor system for enzymatic synthesis of

1995-06-06

1997-05-13

Beisner, William H.

Chemistry: molecular biology and microbiology

Apparatus

Including condition or time responsive control means

4352867, 4352887, C12M 136

Patent

active

056292023

ABSTRACT:
Disclosed is an automatic computer-controlled bioreactor system for enzymatic synthesis of L-tryptophan which comprises a bioreactor linked to a computer equipped with an on-line indole assay device, in which the computer controls the feeding of indole, pyruvic acid and/or its salt and an ammonium salt into the bioreactor and feedback-controls the reaction in the bioreactor by indole concentration determined by the on-line indole assay device, wherein the feeding of indole and ammonium salt is controlled by a pre-defined profile that agrees with a tryptophanase activity profile and pyruvic acid and/or its salt is added at a predetermined time.

REFERENCES:
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Perry, "Perry's Chemical Engineering Handbook." McGraw-Hill, USA, 1984, pp. 27-14 to 27-17.
Blanch, et al., "Enzyme Bioreactors Employing Reverse Michelles and Two-Phase Systems", International Bioreactors Symposium, 8th, 1:577-590 (1988).
Abstract of Vorlop, et al., "Use of Gas Sensor Systems in Bioreactor Control--e.g. During Ethanol or Tryptophan Production; Systems Control".
Abstract of Japanese Patent 1104186 dated Apr. 1989.
Abstract of French Patent 2581654, dated Nov. 1986.
Abstract of Japanese Patent 5685291 dated Jul. 1981.
Abstract of Japanese Patent 62134094 dated Jun. 1987.
Abstract of Japanese Patent 63137689 dated Jun. 1988.
Abstract of Japanese Patent 6451093 dated Feb. 1989.
Abstract of Japanese Patent 1191692 dated Aug. 1989.

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