Computer-based methods and articles of manufacture for preparing

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435 695, 4351723, 4352402, 4352523, C12N 1500, G06F 1700, G06F 1900

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055814760

ABSTRACT:
Provided are computer-based methods for preparing G-CSF analogs involving (a) providing computer expression of the three dimensional structure of a G-CSF molecule wherein the chemical moieties, such as each amino acid residue or each atom of each amino acid residue of the G-CSF molecule are correlated with said structure: (b) selecting from said computer expression a site on a G-CSF molecule for alteration; and (c) preparing a G-CSF molecule having such alteration. Also provided are articles of manufacture associated with such methods.

REFERENCES:
patent: 4810643 (1989-03-01), Souza
patent: 4853871 (1989-08-01), Pantoliano et al.
patent: 4904584 (1990-02-01), Shaw
patent: 4908773 (1990-08-01), Pantoliano et al.
patent: 5265030 (1993-11-01), Skolnick et al.
patent: 5307287 (1994-04-01), Cramer et al.
patent: 5386507 (1995-01-01), Teig et al.
Abdel-Meguid et al., PNAS-USA 84: 6434 (1987).
Abrahmsen et al., Biochem. 30: 4151-4159 (1991).
Weber et al., Physical principles of protein crystallization. In: Eisenberg (ed.), Advances in Protein Chemistry 41:1-36 (1991).
Bazan, Immunology Today 11: 350-354 (1990).
Carter and Carter, J. Biol. Chem. 254:12219-12223 (1979).
Carter et al., J. Cryst. Growth 90: 60-73 (1988).
Cox and Weber, J. Appl. Crystallogr. 20: 366-373 (1987).
Cox and Weber, J. Cryst. Growth 90: 318-324 (1988).
Cunningham and Wells, Science 244: 1081-1084 (1989).
Diederichs et al., Science 254: 1779-1782 (1991).
Francis, Focus on Growth Factors 3: 4-10 (May 1992) (published by Mediscript, Mountview Court, Friern Barnet Lane, London N20 OLD, UK).
Gabrilove, J. Seminars in Hematology 26: (2) 1-14 (1989).
Hill et al., Proceedings of the National Acad. of Sciences of USA, 90: 5167-5171 (1993).
Huse et al., Science 246:1275 (1989).
Ishikawa et al., Cell Structure and Function, 17: 61-65 (1992).
Jancarik and Kim' J. App. Crystallogr. 24: 409 (1991).
Jones et al., Bailliere's Clinical Hematology 2 (1): 83-111 (1989).
Karplus, Protein Engineering, pp. 35-44 (1987).
Kuga et al., Biochem. Biophy. Res. Comm 159: 103-111 (1989).
Layton et al., JBC 266: 23815-23823 (1991).
Layton et al., J. of Cell Biochem. Suppl. 17B: 78 (1993).
Lieshke and Burgess, N. Engl. J. Med. 327: 28-34 and 99-106 (1992).
Lu et al., Arch. Biochem. Biophys. 268: 81-92 (1989).
McKay Science 257: 1673-1677 (1992).
Moore et al., PNAS-USA 84: 7134-7138 (1987).
Nagata et al., EMBO J 5: 575-581 (1986).
Nicola, Annu. Rev. Biochem. 58: 45-77 (1989).
Nicola, et al., Blood 54: 614-27 (1979).
Olson et al., Pour La Science, 183: 76-82 (1993).
Osslund et al., Dissertation Abstracts International B., 54: 1239 (1993).
Pandit et al., Science, 258: 1358-1362 (1992).
Parry et al., J. Molecular Recognition 8: 107-110 (1988).
Powers et al., Science 256: 1673-1677 (1992).
Remington's Pharmaceutical Sciences, 18th Ed. (1990, Mack Publishing Co., Easton, Pennsylvania 18042) pp. 1435-1712.
Senda et al., EMBO J. 11: 3193-3201 (1992).
Smith et al., J. Mol. Biol. 224: 899-904 (1992).
Souza et al., Science 232: 61-65 (1986).
Stryer, Biochemistry, 3d Ed., W. H. Freeman and Company, N.Y. 1988, inside back cover).
Vos et al., Science 255: 305-312 (1992).
Weber, J. Appl. Crystallogr. 20: 366-373 (1987).
Welte et al., PNAS-USA 82: 1526-1530 (1985).
Rastetter, Trends in Biotechnology, 1(3): 80-84, 1983.
Hill et al, PNAS 90, 1993 pp. 5167-5171.
Layton et al JBC 266(35) 1991, pp. 23815-23823.
Najahara et al, J. Mol Biol 214, 1990, pp. 25-26.
Lonejay et al J. Mol Biol 234, 1993, pp. 640-653.
Li et al, JBC 268(30) 1993, pp. 22377-22384.

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