Computer-assisted design of anti-peptides based on the amino aci

Details Computer-assisted design of anti-peptides based on the amino aci Computer-assisted design of anti-peptides based on the amino aci

1989-03-13

1992-01-14

Teska, Kevin J.

Boots, shoes, and leggings

364496, 435 691, 436 89, 935 78, 935 87, G06F 1542, G01N 3368

Patent

active

050815849

ABSTRACT:
A computer-implemented method for designing at least one anti-peptide sequence having affinity for target peptide or a fragment thereof suitable for synthesizing peptides and micromolecules, assaying for a target peptides, purifying target peptides, and/or preventing proteolyis of a polypeptide includes identification of the members of the amino acid sequence of the target peptide and their anti-sense or hydropathically complementary amino acids and determining the moving average hydropathy for the target and anti-sense members. The resulting lowest hydropathy identifies the anti-sense amino acid sequence for the target peptide. The members of the target peptide amino acid sequence are obtained along with their member-specific hydropathic values with the hydropathic values summed as a moving average. Anti-sense or complementary amino acid members are identified from the moving average information to generate an array of anti-sense amino acid sequences. The hydropathic values of the array of anti-sense amino acids are obtained along with their moving average hydropathic values from which a hydropathic complementary score is obtained with the lowest score identifying the anti-sense amino acid sequence having affinity for the target peptide.

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