Computer algorithm for automatic allele determination from...

Details Computer algorithm for automatic allele determination from... Computer algorithm for automatic allele determination from...

2007-09-18

2007-09-18

Brusca, John S. (Department: 1631)

Data processing: measuring, calibrating, or testing

Measurement system in a specific environment

Biological or biochemical

C435S006120

Reexamination Certificate

active

10085142

ABSTRACT:
The present invention provides methods and systems for an automated method of identifying allele values from data files derived from processed fluorophore emissions detected during the observation of fluorophore labeled nucleotide probes used in analyzing polymorphic DNA are provided. These methods are used in the rapid and efficient distinguishing of targeted polymorphic DNA sites without control samples.

REFERENCES:
Heil, et al. An Automated Computer System to Support Ultra High Throughput SNP Genotyping. Pacific Symposium on Biocomputing. Jan. 3-7, 2002. p. 30-40.
Rao et al., NAR, vol. 31, No. 11, e. 66, p. 1-8, 2003.
King (Jour. Am. Stat. Assoc., vol. 69, p. 86-101, Mar. 1967).
Mein C A et al: “Evaluation of single nucleotide polymorphism typing with invader on PCR amplicons and its automation”, Genome Research 2000 United States, vol. 10, No. 3, 2000, pp. 330-343.
Ranade K et al: “High-throughput genotyping with single nucleotide polymorphisms”, Genome Research 2001 United States, vol. 11, No. 7, 2001, pp. 1262-1268.
Chen X et al: “Homogeneous genotyping assays for single nucleotide polymorphisms with fluorescence resonance energy transfer detection”, Genetic Analysis: Biomolecular Engineering, Elsevier Science Publishing, US, vol. 14, No. 5-6, Feb. 1999, pp. 157-163.
Livak K J: “Allelic discrimination using fluorogenic probes and the 5′ nuclease assay”, Genetic Analysis: Biomolecular Engineering, Elsevier Science Publishing, US, vol. 14, No. 5-6, Feb. 1999, pp. 143-149.
Fujisawa H et al: “Genotyping of single nucleotide polymorphism using model-based clustering”, BIOINFORMATICS Mar. 22, 2004 United Kingdom, vol. 20, No. 5, Mar. 22, 2004, pp. 718-726.

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