Computer-aided visualization and analysis system for sequence ev

Details Computer-aided visualization and analysis system for sequence ev Computer-aided visualization and analysis system for sequence ev

1994-10-21

1998-08-18

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 911, 435 912, 382178, 382179, 364 96, 364 97, 364 98, 364 99, 536 243, 536 2433, 536 2432, 536 231, C12Q 168, C12P 1934, G06F 1546, C07H 2104

Patent

active

057957169

ABSTRACT:
A computer system for analyzing nucleic acid sequences is provided. The computer system is used to perform multiple methods for determining unknown bases by analyzing the fluorescence intensities of hybridized nucleic acid probes. The results of individual experiments are improved by processing nucleic acid sequences together. Comparative analysis of multiple experiments is also provided by displaying reference sequences in one area and sample sequences in another area on a display device.

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Drmanac et al. DNA Sequence Determination by hybridization:A strategy for Effeicient Large Scale Sequencing. Science: 260: 1649-1652, 1993.
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Southern et al. Analyzing and Comparing Nucleic Acid Sequences by Hybridization to Arrays of Oligonucleotides: Evaluation using Experimentals Models. Genomics 13: 1008-1017, 1992.

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