Computer-aided engineering system for design of sequence arrays

Details Computer-aided engineering system for design of sequence arrays Computer-aided engineering system for design of sequence arrays

1996-09-27

1999-01-05

Elliott, George C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

4352851, 4352872, C12Q 168, C12M 304, C12M 134

Patent

active

058561013

ABSTRACT:
An improved set of computer tools for forming arrays. According to one aspect of the invention, a computer system (100) is used to select probes and design the layout of an array of DNA or other polymers with certain beneficial characteristics. According to another aspect of the invention, a computer system uses chip design files (104) to design and/or generate lithographic masks (110).

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patent: 5288514 (1994-02-01), Ellman
patent: 5571639 (1996-11-01), Hubbell et al.
Brown et al., "An Inexpensive MSI/LSI Mask Making System," Symposium Proceedings University Government Industry Microelectronic Symposium, pp. III-31 to III-38 (1981).
Ferrari et al., "Minimal rectangular Partitions of Digitized Blobs," IEEE, pp. 1040-1043 (1980).
Fodor et al., "Light-Directed, Spatially Addressable Parallel Chemical Synthesis," Science, V. 251, pp. 767-773 (1991).
Lipski, "Finding a Manhattan Path and Related Problems," Networks, V. 13, pp. 399-409 (1983).
Mead et al., Introduction to VLSI Systems, pp. 93-98 (1980).
Parnzblau et al., "An Algorithm for Construction Regions with Rectangles: Independence and Minimum Generating Sets for Collections of Intervals," ACM, pp. 167-174 (1984).
USSN 08/143,312 filed Oct. 26, 1993, entitled "Arrays of Nucleic Acid Probes on Biological Chips."

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