Computational subtraction method

Details Computational subtraction method Computational subtraction method

2006-02-07

2006-02-07

Allen, Marianne P. (Department: 1647)

Data processing: measuring, calibrating, or testing

Measurement system in a specific environment

Biological or biochemical

C702S019000, C707S793000, C707S793000, C707S793000

Reexamination Certificate

active

06996477

ABSTRACT:
The invention provides a method and system for performing computational subtraction to detect microbes within a host organism. In some aspects, the microbes are pathogens and the system is used to identify sequences belonging to these pathogens which can then be used in methods of diagnosis and treatment. Alternatively, the microbes can be symbiotic organisms, such as commensal or parasitic organisms. Preferably, candidate sequences identified as belonging to a microbe are used to isolate and clone additional sequences from the microbe.

REFERENCES:
patent: 5966711 (1999-10-01), Adams
patent: 5966712 (1999-10-01), Sabatini et al.
patent: 6114114 (2000-09-01), Seilhammer et al.
patent: 6185561 (2001-02-01), Balaban et al.
patent: 6303297 (2001-10-01), Lincoln et al.
patent: WO 01/54557 (2001-08-01), None
Relman et al. Nature Genetics, 30(2):131-133, Feb. 2002.
Weber et el., Nature Genetics, 30(2):141-142, Feb. 2002, including supplementary information from web site.
Cummings and Relman, Using DNA Microarrays to Study Host-Microbe Instructions,Emerg. Infect. Dis6(5):513-525 (2000).
Lisitsyn, Representational difference analysis: finding the differences between genomes,Trends Genetics11:303-307 (1995).
Maiwald et al, Whipple's Disease andTropheryma whippelii: Secrets Slowly Revealed,Clin Infect. Dis32(3):457-463 (2002).
Relman et al, The Agent of Bacillary Angiomatosis,New England. J. Med. 323:1573-1580 (1990).
Wan, et al, Cloning Differentially Expressed mRNAs,Nature Biotechnology, 14:1685-1691 (1996).
International Search Report PCT/US01/12736.
Zhang et al., “A Greedy Algorithm for Aligning DNA Sequences,” Journal of Computational Biology 7 (1/2): 203-214(2001).
Balter, “Molecular Methods Fire Up the Hunt for Emerging Pathogens,” Science 282: 21-23 (1998).
Fredericks et al., “Application of Polymerase Chain Reaction to the Diagnosis of Infectious Diseases,” CID 29:475-488 (1999).

Affiliated with

Also associated with

Rating

Computational subtraction method does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Computational subtraction method, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Computational subtraction method will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3684806