Computational analysis of nucleic acid information defines bindi

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364578, G06F 1716

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058674020

ABSTRACT:
In accordance with the present invention, binding sites are defined based upon the individual information content of a particular site of interest. Substitutions within the binding site sequences can be analyzed to determine whether the substitution will cause a deleterious mutation or a benign polymorphism. In addition, new binding sites can be identified using individual information content. Further a computer system is described for determining and displaying individual information content of a binding site sequence.

REFERENCES:
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Schnider, T. "Poster on Information Theory and Individual Information," Web page at http://www-lmmb.ncifcrf.gov/.about.toms/just.say.no/index.html, Feb. 27, 1996--updated Oct. 18, 1996.
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Nathan D. Herman, et al., "High Information Conservation Implies that at Least Three Proteins Bind Independently to F Plasmid incD Repeats," Journal of Bacteriology, pp. 3558-3560, Jun. 1992.
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