Compstatin analogs with improved activity

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 11 to 14 amino acid residues in defined sequence

Reexamination Certificate

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C514S001100, C424S001690

Reexamination Certificate

active

07989589

ABSTRACT:
Compounds comprising peptides and peptidomimetics capable of binding the C3 protein and inhibiting complement activation are disclosed. These compounds display improved complement activation-inhibitory activity as compared with currently available compounds. Isolated nucleic acid molecules encoding the peptides are also disclosed.

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Non-Final Office Action in U.S. Appl. No. 11/605,182, mailed Jun. 30, 2009.
Final Office Action in U.S. Appl. No. 11/605,182, mailed Mar. 3, 2010.
Notice of Allowance in U.S. Appl. No. 11/605,182, mailed Sep. 27, 2010.

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