Compressible starches as binders for tablets or capsules

Details Compressible starches as binders for tablets or capsules Compressible starches as binders for tablets or capsules

1984-04-23

1985-11-05

Morris, Theodore

Compositions: coating or plastic

Coating or plastic compositions

Carbohydrate or derivative containing

106213, 127 32, 127 71, 536102, C08B 3100, C08L 300

Patent

active

045511772

ABSTRACT:
A compressible starch, useful as a binder for tablets prepared by direct compression or dry granulation or as a binder-diluent for capsules, is prepared by treating a cold-water-insoluble, granular starch (e.g., corn or waxy corn starch) with an acid, and/or alpha-amylase enzyme at a temperature below the starch's gelatinization temperature. The treated starch is characterized by altered, weakened granules with a less dense interior and disrupted surface. The compressible starch when admixed with a wet granulation binder (e.g., pregelatinized starch) is useful as a binder for tablets prepared by wet granulation as well as direct compression or dry granulation or as a binder-diluent for capsules.

REFERENCES:
patent: 1677615 (1928-07-01), Boidin
patent: 2056104 (1936-09-01), Hueter
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patent: 4384005 (1983-05-01), McSweeney

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