Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Reexamination Certificate
2011-06-14
2011-06-14
Loewe, Sun Jae Y (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
C546S276100
Reexamination Certificate
active
07960365
ABSTRACT:
The invention provides for compounds having the structure according to the formula Iwherein: X is a carbon or nitrogen atom; Ar is phenyl or heteroaromatic ring; R1is hydrogen, halogen, CN or (1C-4C)alkyl; R2is hydrogen, halogen or optionally fluorinated (1C-3C)alkoxy; R3and R5are independently hydrogen, optionally halogenated (1C-4C)alkyl, optionally halogenated (1C-4C)alkoxy, optionally halogenated aryl(1C-4C)alkoxy, optionally halogenated (1C-4C)alkenyl or hydroxylmethyl; R4is hydrogen, halogen, optionally halogenated (1C-4C)alkoxy or optionally halogenated aryl(1C-4C)alkoxy; R6is hydrogen, benzyl, optionally substituted with one or more halogens or (1C-4C)alkyl, or R6is optionally halogenated (1C-4C)alkyl; each R7independently is hydrogen, halogen, optionally halogenated (1C-4C)alkyl or optionally halogenated (1C-4C)alkoxy and pharmaceutically suitable acid addition salts thereof for use as glucocorticoid receptor modulators, in particular for treatment of central nervous system disorders.
REFERENCES:
patent: WO 96/36595 (1996-11-01), None
patent: WO 2004/019935 (2004-03-01), None
patent: WO 2006/009876 (2006-01-01), None
patent: WO 2006/046914 (2006-05-01), None
Dyke et al., caplus an 1997:51534.
Ornstein et al., caplus an 2000:746417 (2000).
Beato, et al., “DNA Regulatory Elements for Steroid Hermones,”J. Steroid Biochem., 32, 1989, 737-747.
Ellman, et al., “N-tert-Butanesulfinyl Imines: Versatile Intermediates for the Asymmetric Synthesis of Amines,”Acc. Chem. Res., 35, 2002, 984-995.
Miyaura, et al., “Palladium-Catalyzed Cross-Coupling Reactions of Organoboron Compounds,”Chem. Rev., 95, 1995, 2457-2483.
Nicolaou, et al., “Palladium-Catalyzed Cross-Coupling Reactions in Total Synthesis,”Angew. Chem. Intl. Edn., 44, 2005, 4442-4489.
Database Beilstein, Beilstein Institute for Organic Chemistry, Frankfurt-Main, DE; XP002429082 retrieved from XFIRE Database accession No. 7773424, 1982.
Database Chemcats, Chemical Abstracts Service, Columbus, Ohio, US; XP002429083; Accession No. 2005:1526101.
Database Caplus (Online), Chemical Abstracts Service, Columbus, Ohio, US; Miyazaki, Daichi et al.: “Enantioselective Borodeuteride Reduction of Aldimines Catalyzed by Cobalt Complexes: Preparation of Optically Active Deuterated Primary Amines”, XP002429084, retrieved from STN Database accession No. 2003:685332.
Database Chemcats, Chemical Abstracts Service, Columbus, Ohio, US; XP002429085; Accession No. 2006:2959389.
Mac Pherson, L. et al., “Discovery of CGS 27023A, a Non-Peptidic, Potent, and Orally Active Stromelysin Inhibitor That Blocks Cartilage Degradation in Rabbits”, J. Med. Chem. 40(16):2525-2532 (1997).
Mac Pherson, L. et al., pp. 1-2, Abstract. DOI: 10.1021/jm960871c; ISSN: 0022-2623; CrossFire Beilstein Database, Elsevier Information Systems GmbH (2007-2008).
Miyazaki, D. et al., “Enantioselective Borodeuteride Reduction of Aldimines Catalyzed by Cobalt Complexes: Preparation of Optically Active Deuterated Primary Amines”,Organic Letters5(20):3555-3558 (2003).
International Search Report for PCT/EP2006/069814 dated Apr. 25, 2007; and Written Opinion for PCT/EP2006/069814 dated Apr. 25, 2007.
Brown Angus Richard
Grove Simon James Anthony
Hamilton Niall Morton
Ho Koc-Kan
Kiczun Michael John
Devlin Gerard M.
Hess Susan L.
Loewe Sun Jae Y
N.V. Organon
LandOfFree
Compounds with medicinal effects due to interaction with the... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compounds with medicinal effects due to interaction with the..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds with medicinal effects due to interaction with the... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2676564