Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1996-12-18
1999-11-02
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
564153, 564155, 564345, A61K 3116, C07C23301
Patent
active
059771780
ABSTRACT:
Compounds of peptide mimetic nature having the general formula I ##STR1## wherein a and b are independently 1 or 2, R.sup.1 and R.sup.2 are independently H or C.sub.1-6 alkyl, G and J are independently, inter alia, aromats, and D and E are independently several different groups are growth hormone secretagogous with improved bioavailability.
REFERENCES:
McDowell et al., Proc. Nat'l. Acad. Sci., USA, Biochem., vol. 92, pp. 11165-11169 (Nov. 1995).
Elias et al., The Endocrine Society, vol. 136, No. 12, pp. 5694-5699 (Dec. 1995).
Ankersen Michael
Hansen Thomas Kruse
Lau Jesper
Lundt Behrend Friedrich
Madsen Kjeld
Aulakh Charanjit S.
Lambiris Elias J.
Novo Nordisk A S
Rotman Alan L.
Rozek Carol E.
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