Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-07-17
2000-01-11
Chang, Ceila
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514326, 514666, 546209, 548131, 564502, C07D27106, A61K 3141
Patent
active
060136588
ABSTRACT:
There are disclosed novel synthetic peptides of formula (I) ##STR1## where A, B, D, E, F, G, J, m, n, and p are defined in the specification. Compounds of formula (I) promote the release of growth hormone in humans and animals. Growth promoting compositions containing such compounds of formula (I) as the active ingredient, methods of stimulating the release of growth hormone, and the use of such compounds of formula (I) are also disclosed.
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Borg et al. "Synthesis or 1,2,4-oxadiazole, 1,3,4-oxidiazole and 1,2,4-triazole derivative dipeptidomimetics" J. Or. Chem. v.60, 3112-3120, 1995.
McDowell et al., "Growth Hormone Secretagogues: Characterization, Efficacy, and Minimal Bioactive Conformation" Proc. Natl. Acad. Sci. USA, vol. 92. pp. 11165-11169, Nov. 1995, Biochemistry.
Elias et al., "In Vitro Characterization of Four Novel Classes of Growth Hormone-Releasing Peptide", Endocrinology, vol. 136, No. 12. pp. 5694-5699 (1995).
Ankersen Michael
Hansen Thomas Kruse
Johansen Nils Langeland
Lau Jesper
Peschke Bernd
Chang Ceila
Novo Nordisk A S
Rozek Carol E
Zelson Steve T.
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