Compounds with growth hormone releasing properties

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

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514255, 514307, 514319, 514400, 514419, 514428, 514438, 514443, 544400, 546146, 546205, 5483381, 548495, 548567, 548568, 549 58, 549 76, 564157, A61K 31165, C07C23311, C07C23534, C07C23722

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active

059227702

ABSTRACT:
Novel peptide derivatives, compositions containing them, and their use for treating medical disorders resulting from a deficiency in growth hormone are disclosed. The peptides have the formula (I): ##STR1## wherein a, b, A, R.sup.1, L.sup.1, D, R.sup.3, R.sup.4, R.sup.2, L.sup.2, E and G are as defined in the specification. These peptides exhibit improved resistance to proteolytic degradation, and hence, improved bioavailability.

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