Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1998-06-25
2000-12-26
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514183, 514836, 424 9, G01N 2408, C07B 4700, A61K 31675
Patent
active
061659967
ABSTRACT:
This invention involves synthesis and use of a class of compounds with chelation affinity and selectivity for first transition series elements. Administration of the free or conjugated compound, or physiological salts of the free or conjugated compound, results in decrease in the in vivo bioavailability of first transition series elements and/or removal from the body of first transition series elements and elements with similar chemical properties. These characteristics make such compounds useful in the management of diseases associated with a bodily excess of first transition series elements and elements with similar chemical properties. This invention demonstrates that such compounds inhibit mammalian, bacterial, and fungal cell replication and are therefore useful in the treatment of neoplasia, infection, inflammation, immune reponse, and in termination of pregnancy. Since these compounds are capable of descreasing the in vivo availability of tissue iron they are useful in management of free radical mediated tissue damage, and oxidation mediated tissue damage. When combined with radioisotopic or paramagnetic cations of first transition series elements, or elements with chemical properties similar to those of first transition series elements, prior to their administration, the resulting complexes are useful as diagnostic agents in nuclear medicine and magnetic resonance imaging (MRI).
REFERENCES:
patent: 3524854 (1970-08-01), Kuhn
patent: 3833562 (1974-09-01), Fonken et al.
patent: 4022833 (1977-05-01), Diana et al.
patent: 5663161 (1997-09-01), Bell
L. Mishra and A.K. Pandey, Chemical Abstracts (Jul. 13, 1992) 117(2): 785.
G.J. Bridger et al., Journal of Medicinal Chemistry (1996) 39: 109-119.
G.J. Bridger et al., Journal of Medicinal Chemistry (1995) 38(2): 366-378.
T.M. Jones-Wilson et al., Nucl. Med. Biol. (1995) 22(7): 859-868.
M. Loyevsky et al.,Biochemical Pharmacology (1997) 54(4): 451-458.
Cyjon Rosa L
Klein Joseph Y
Klein Ofer
Simhon Elliot D
Winchell Harry S
Concat, Inc.
Shah Mukund J.
Sripada Pk
LandOfFree
Compounds with chelation affinity selectivity for first transiti does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compounds with chelation affinity selectivity for first transiti, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds with chelation affinity selectivity for first transiti will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-994979