Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-12-13
2005-12-13
Huang, Evelyn Mei (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S426000, C546S223000, C546S224000, C548S557000
Reexamination Certificate
active
06974825
ABSTRACT:
Compounds of general formula (I)wherein m is 0 or 1, and n is 1 or 2;are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.
REFERENCES:
patent: 4091096 (1978-05-01), Beck et al.
patent: 4126689 (1978-11-01), Sanczuk et al.
patent: 4460586 (1984-07-01), Berthold
patent: 4680296 (1987-07-01), Manoury et al.
patent: 5118693 (1992-06-01), Toth et al.
patent: 5132303 (1992-07-01), Toth et al.
patent: 5132309 (1992-07-01), Toth et al.
patent: 5854245 (1998-12-01), Duggan et al.
patent: 6153626 (2000-11-01), Pelcman et al.
patent: 6399635 (2002-06-01), Pelcman et al.
patent: 6436959 (2002-08-01), Carson et al.
patent: 28 22 465 (1978-11-01), None
patent: 206 677 (1989-08-01), None
patent: WO 98/28270 (1998-07-01), None
patent: WO 99/33806 (1999-07-01), None
patent: WO 99/45925 (1999-09-01), None
Adachi, et al., “Aminohaloborane in Organic Synthesis. IX. Exclusive Ortho Acylation Reacfdtion of N-Monoaminoalkylanilines,” XP002277753, Database Chemabs Online, Accession No. 1987:49715,Chemical&Pharmaceutical Bulletin 33(5):1826-1835 (1985).
Burkartsmaier, et al., “Potential Analgesics, IX: Synthesis and Pharmacological Test of Substituted N-(Piperidin-4-yl)Anthranilic Acid Derivatives,” XP002277757, Database Chemabs Online, Accession No. 1979:54780,Archiv. der Pharmazie 311(10):843-848 (1978).
Deruiter, et al., “Investigation of the Synthesis and Analgesic Activity of 1-Substituted 4-(Propananilido) Perhydroazepines,” XP002277751, Database Chemabs Online, Accession No. 1992:612296,J. Heterocyclic Chem. 29(4):779-786 (1992).
Ferrand, et al., “Synthesis of new 1,2,3-triazin-4-Ones as Potential Antidepressants,” XP002277752, Database Chemabs Online, Accession No. 1988:150431,Eur. J. Medicinal Chem. 22(4):337-345 (1987).
Obase, et al., “New Antihypertensive Agents. III. Synthesis and Antihypertensive Activity of Some Arylalkyl Piperidines Carrying a Heterocycle at the 4-Position,” XP002277758, Database Chemabs Online, Accession No. 1984:120835,Chemical&Pharmaceutical Bulletin 31(9):3186-3197 (1983).
Sugasawa, et al., “1-Azacycloalkyl-1,4-Benzodiazepin-2-Ones with Antianxiety-Antidepressant Actions,” XP002277755, Database Chemabs Online, Accession No. 1985:437458,J. Medicinal Chem. 28(6):699-707 (1985).
Takai, et al., “Synthesis and Pharmacological Evaluations of Piperidine Derivatives with Various Heterocyclic Rings at the 4-Position,” XP002277754, Database Chemabs Online, Accession No. 1985:578235,Chemical&Pharmaceutical Bulletin 33(3):1104-1115 (1985).
Wang, et al., “Opioid .Delta. Receptor Irreversible Inhibitors. 2. Synthesis of Isothiocyanate Derivatives of Carfentanil and 4-(Methoxymethyl)Fentanyl,” XP002277750, Database Chemabs Online, Accession No. 1995:857886,Chinese Chemical Letters 6(9):763-764 (1995).
Zhu, et al., “Studies on Potent Analgesics. I. Synthesis and Analgesic Activity of Fentanyl Derivatives,” XP002277756, Database Chemabs Online, Accession No. 1981:550311,Yaoxue Xuebao 16(3):199-210 (1981).
Bilsky, et al., SNC 80, A Selective, Nonpeptidic and Systemically Active Opioid Delta Agonist,J. Pharmacol. Experi. Ther. 273:359-366 (1995).
Enein, et al., Abstract #159379n, “Synthesis of Some 4-Substituted Amino-1-Methyl Piperidines Structurally Related to Antihistaminics,”Chem. Abstr.,vol. 78, No. 25, p. 396 (1973).
Laskowska, Abstr. #105299e, “1-Methyl-4-[N-phenyl-N-(2-thienyl)amino]piperidine,”Chem. Abstr.,vol. 81, No. 17, p. 510 (1975).
Podlogar, et al., “Synthesis and Evaluation of 4-(N,N-Diarylamino)piperidines with High Selectivity to the 8-Opioid Receptor: A Combined 3D-QSAR and Ligand Docking Study,”Drug Design and Discovery,34-50 (2000).
Sarges, et al., “Neuroleptic Activity of Chiral trans-Hexahydro-γ-Carbolines,”J. Med. Chem. 29:8-19 (1986).
Takemori, et al., “Selective Natrexone-Derived Opioid Receptor Antagonists,”Annu. Ref. Pharmacol. Toxicol. 32:239-269 (1992).
Abstract for DE 28 22 465, Reference AK1 above.
Abstract for HU 206 677, Reference AH2 below.
English language abstract for HU 206 677, Reference AH2 above.
Pelcman Benjamin
Roberts Edward
AstraZeneca Canada Inc.
Fitch Even Tabin & Flannery
Huang Evelyn Mei
Sanzo Michael A.
LandOfFree
Compounds with analgesic effect does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compounds with analgesic effect, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds with analgesic effect will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3487131