Compounds which release nitric oxide upon illumination

Organic compounds -- part of the class 532-570 series – Organic compounds – Diazoamino

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534556, 534569, 423405, C07C24502, C07C24524, C01B 2124

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active

053747100

ABSTRACT:
Chemical derivatives of nitric oxide are provided which are stable indefinitely in oxygen-containing solutions until photolysis, whereupon they release NO. These compounds have the general formula

REFERENCES:
patent: 3714351 (1973-01-01), Gubler
patent: 3907767 (1975-09-01), Hess et al.
patent: 3962434 (1976-06-01), Miesel
patent: 4297096 (1981-10-01), Yoshida et al.
patent: 5155137 (1992-10-01), Keefer et al.
Behera et al, Spectrochimica Acta, vol. 27A, pp. 2273 to 2275 (1971).
Adams, et al., "Controlling Cell Chemistry with Caged Compounds", Annu. Rev. Physiol. 55:755-84 (1993).
Bliss, et al., "A Synaptic Model of Memory: Long-Term Potentiation in the Hippocampus", Nature 361:31-39 (7 Jan. 1993).
Bohn et al., "Oxygen and Oxidation Promote the Release of Nitric Oxide from Sydnonimines", J. Cardiovascular Pharm. 14(Suppl. II):S6-S12 (1989).
Boulton et al., "Nitric Oxide Induces Transient Synaptic Depression in Rat Hippocampal Slices", J. Physiol. Abstract C37 p. 51P (Leeds Meeting 1993).
Carter et al., "Photochemical Release of Nitric Oxide form Ruthenium Nitrosyl Trichloride: Relaxation of Rabbit Isolated Aortic Rings Mediated by Photo-release of Nitric Oxide", J. Physiol. Abstract C20 p. 34P (Leeds Meeting 1993).
Drago et al., "The Reaction of Nitrogen (II) Oxide with Various Primary and Secondary Amines", J. Am. Chem. Soc. 83:1819-1822 (1961).
Drago et al., "The Reaction of Nitrogen (II) Oxide with Diethylamine", J. Am. Chem. Soc. 82:90-98 (1960).
Flitney et al., "Photochemical Release of Nitric Oxide from Iron-Sulphur Cluster Nitrosyls: Laser Potentiation of Vasodilator Actions on Rat Isolated Tail Artery", J. Physiol. 459:90P (1993).
Flitney et al., "Selective Retention of Iron-Sulphur Cluster Nitrosyls in Endothelial Cells of Rat Isolated Tail Artery: Association with Protracted Vasodilator Responses", J. of Physiol. 459:89P (1993).
Hallam et al., "Agonists Stimulate Divalent Cation Channels in the Plasma Membrane of Human Platelets", FEBS Lett. 186175-179 (1985).
Hrabie et al., "New Nitric Oxide-Releasing Zwitterions Derived from Polyamines", J. Org. Chem. 58:1472-1476 (1993).
Maragos et al., "Complexes of NO with Nucleophiles as Agents for the Controlled Biological Release of Nitric Oxide", J. Med. Chem. 34:3242-3247 (1991).
McCray et al., "Properties and Uses of Photoreactive Caged Compounds", Annu. Rev. Biophys. Chem. 18:239-70 (1989).
Moncada et al., "Nitric Oxide: Physiology, Pathophysiology, and Pharmacology", Pharmacalog. Review 43:109-142 (1991).
Saavedra et al., "Secondary Amine/Nitric Oxide Comples Ions, R.sub.2 N[N(O)NO] O-Functionalizaiton Chemistry", J. Org. Chem. 57:6134-6138 (1992).
Williams et al., "Photolytic Release of Nitric Oxide from Ruthenium Nitrosyl Chloride Depresses an APS-Sensitive Response But Does Not Induce Long-Term Potentiation in Area CA1 of the Rat Hippocampus In Vitro", J. Physiol. Abstract C19 p. 33P (Leeds Meeting 1993).

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