Compounds which prevent neuronal cell death and uses thereof

Details Compounds which prevent neuronal cell death and uses thereof Compounds which prevent neuronal cell death and uses thereof

2006-10-24

2006-10-24

Navarro, Mark (Department: 1645)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

C530S350000, C514S002600

Reexamination Certificate

active

07125956

ABSTRACT:
The present invention provides for a compound having the structure: (AA1)n-Cys-(AA2)mwherein n=0,1,2,3,4 or 5 and m=0,1,2,3,4 or 5, provided the sum of (n+m) is greater than or equal to two and less than or equal to five, if n=1, (AA1)n=Ala-, if n=2, (AA1)n=Gln-Ala-, if n≧3, (AA1)n=(Xaa)p-Gln-Ala-, and Xaa=any amino acid and wherein if n=n3, p=1, if n=4, p=2, if n=5, p=3, if m=1, (AA2)m=-Arg, if m=2, (AA2)m=-Arg-Gly, if m≧3, (AA2)m=-Arg-Gly-(Xaa)q, wherein if m=3, q=1, if m=4, q=2, if m=5, q=3. The present invention provides for a method of inhibiting cell death and a method for alleviating symptoms of a neurodegenerative disorder in a subject.

REFERENCES:
patent: 5672500 (1997-09-01), Litwack et al.
patent: 6635738 (2003-10-01), Troy et al.
patent: 2002/0044931 (2002-04-01), Troy et al.
patent: 425212 (1991-05-01), None
patent: 533350 (1999-05-01), None
Barinaga, M. (1994) Cell Suicide: By ICE, Not Fire.Science263.: 754-756.
Casciola-Rosen, L.A. et al. (1994) Specific Cleavage of the 70-kDa Protein Component of the Ul Small Nuclear Ribonucleoprotein Is a Characteristic Biochemical Feature of Apoptotic Cell Death.J. Bio. Chem. 269 (49) : 30757-30760.
Derossi, D., et al. (1996) Cell Internalization of the third helix ofAntennapediahomeodomain is receptor-independent.J. Biol. Chem. 211, 18188-93.
Duggan, M.E. et al. (1995) Non-Peptide Fibrinogen Receptor Antagonists. 7. Design and Synthesis of a Potent, Orally Active Fibrinogen Receptor Antagonist.J. of Med. Chem. 38(17) : 3332-3341.
Enari, M., Hug, H. and Nagata, S. (1995) Involvement of an Ice-like protease in Fas-mediated apoptosis.Nature375:78-81.
Fernandes-Alnemri, T., Litwack, G. and Alnemri, E. S. (1995) Mch2, a New Member of the Apoptotic Ced-3/Ice Cysteine Protease Gene Family.Cancer Res. 55-2737-2742.
Koivunen, E., Gay, D.A. and Ruoslahti, E. (1993) Selection of Peptides Binding to the o^Pi Integrin from Phage Display Library. J.of Biol. Chem. 27:20205-20210.
Los, M. et al. (1995) Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis.Nature375:81-83.
Luo, A.-M. et al. (Nov. 1993) Antigen Mimicry in Autoimmune Disease, Sharing of Amino Acid Residues Critical for Pathogenic T Cell Activation. AIT?.Soc. for Clin. Invest. 92:2117-2123.
Mashima, T. et al. (1995) Aspartate-Based Inhibitor of Interleukin-1 (3-Converting Enzyme Prevents Antitumor Agent-Induced Apoptosis in Human Myeloid Leukemia U937 Cells.Biochem. and Biophys. Res. Comm. 209 (3):907-915.
Milligan, C.E. et al. (1995) Peptide Inhibitors of the ICE Protease Family Arrest Programmed Cell Death of Motoneurons In Vivo and In Vitro.Neuron15:385-393.
Munday, N.A. et al. (1995) Molecular Cloning and Pro-apoptotic Activity of ICErelII and ICErelIII, Membersof the ICE/CED-3 Family of Cysteine Proteases.J. of Biol. Chem. 270 (26) : 15870-15876.
Prochiantz, A. (1996) Getting hydrophilic compounds into cells: lessons from homeopeptides. Curr. Opin. Neurobiol. 6:629-34.
Troy, C. -M. , . et al. (1996) Downregulation- of Cu/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathway. J. Neurosci. 16:253-61.
Wang, L. et al. (1994) Ich-1, an Ice/ced-3-Related Gene. Encodes Both Positive and Negative Regulators of Programmed Cell Death.Cell78:739-750.
Wang, X. et al. (1995) Purification of an Interleukin-13Converting Enzyme-related cysteine Protease That Cleaves Sterol Regulatory Element-binding Proteins between and Leucine Zipper and Transmembrane Domains.J. of Biol. Chem. 270(30) :18044-18055.
Xuan, J.-W. et al. (1995) Site-Directed Mutagenesis of the Arginine-Glycine-Aspartic Acid Sequence in Osteopontin Destroys Cell Adhesion and Migration Functions.J. of Cell. Biochem. 57:680-690.

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