Compounds which potentiate glutamate receptor and uses...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S424000, C514S524000, C514S597000, C514S605000, C548S214000, C548S550000, C558S413000, C564S049000, C564S099000

Reexamination Certificate

active

07741351

ABSTRACT:
This case discloses compounds of formula (I) wherein R1is C1-6alkyl, haloC1-6alkyl, C2-6alkenyl, amino, monoC1-4alkylamino or diC1-4alkylamino; R2and R3, which may be the same or different, are hydrogen, halogen, C1-6alkyl, haloC1-6alkyl, C1-4alkoxy, haloC1-4alkoxy, cyano or amino; each R4, which may be the same or different, is C1-6alkyl, halogen, haloC1-6alkyl, C1-4alkoxy, haloC1-4alkoxy, cyano, nitro or amino; p is 0, 1 or 2; each R5, which may be the same or different, is C1-6alkyl, halogen, haloC1-6alkyl, C1-4alkoxy, haloC1-4alkoxy, cyano, nitro or amino; q is 0, 1 or 2; R6is —NR6aSO2R6b, —NR6aC(═O)R6b, —NR6a(C═O)N(R6c)2, —(C═O)R6d, —CH2NR6aSO2R6b, —CH2NR6aC(═O)R6b, CH2NR6a(C═O)N(R6c)2or —CH2(C═O)R6d; where R6aand each R6c, which may be the same or different, is hydrogen or C1-6alkyl; R6band R6dare C1-6alkyl or haloC1-6alkyl; or R6aand R6b, or R6aand R6c, together with the interconnecting atoms, may form a 5- or 6-membered ring; n is 1 or 2; and R7and R8, which may be the same or different, are hydrogen, halogen, C1-6alkyl, haloC1-6alkyl, C1-4alkoxy, haloC1-4alkoxy, cyano or amino. It also discloses methods for preparing the compounds and their use in therapy such as treating schizophrenia.

REFERENCES:
patent: 6525099 (2003-02-01), Arnold et al.
patent: WO 00/06537 (2000-02-01), None
patent: WO 01/42203 (2001-06-01), None

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