Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-05-03
2011-05-03
Powers, Fiona T (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S352000, C546S282100, C546S289000, C546S309000
Reexamination Certificate
active
07935715
ABSTRACT:
Compound of formula (I)are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
REFERENCES:
patent: 3116284 (1963-12-01), Testa
patent: 3117128 (1964-01-01), Mooradian
patent: 3577462 (1971-05-01), Bruce et al.
patent: 3966809 (1976-06-01), Baker et al.
patent: 4257954 (1981-03-01), Schmidt et al.
patent: 4535087 (1985-08-01), Spatz
patent: 4672065 (1987-06-01), Spatz
patent: 4859707 (1989-08-01), Loftsson et al.
patent: 5256658 (1993-10-01), Hsi et al.
patent: 5428037 (1995-06-01), Pascal et al.
patent: 5475130 (1995-12-01), Sato et al.
patent: 5571921 (1996-11-01), Bender et al.
patent: 5583147 (1996-12-01), Ko et al.
patent: 5656634 (1997-08-01), Chang et al.
patent: 5847153 (1998-12-01), Warpehoski et al.
patent: 5968929 (1999-10-01), Blythin et al.
patent: 6057371 (2000-05-01), Glennon
patent: 6176442 (2001-01-01), Eicher et al.
patent: 6221866 (2001-04-01), Brendel et al.
patent: 6355653 (2002-03-01), Trottmann et al.
patent: 6359009 (2002-03-01), Diehl et al.
patent: 6410792 (2002-06-01), Connell et al.
patent: 6414011 (2002-07-01), Hogenkamp et al.
patent: 6437177 (2002-08-01), Warpehoski et al.
patent: 6453795 (2002-09-01), Eicher et al.
patent: 6528529 (2003-03-01), Brann et al.
patent: 6573278 (2003-06-01), Mittendorf et al.
patent: 6610711 (2003-08-01), Armer et al.
patent: 6737418 (2004-05-01), Hogenkamp et al.
patent: 7476756 (2009-01-01), Almario-Garcia et al.
patent: 7595397 (2009-09-01), Zindell et al.
patent: 2002/0099035 (2002-07-01), Sandanayaka et al.
patent: 2004/0067999 (2004-04-01), Block et al.
patent: 2004/0242913 (2004-12-01), Ducray et al.
patent: 2005/0059663 (2005-03-01), Martin et al.
patent: 2005/0182108 (2005-08-01), Carson
patent: 2006/0061726 (2006-03-01), Okuyama
patent: 2006/0079557 (2006-04-01), Dolle et al.
patent: 2007/0021403 (2007-01-01), Abouabdellah et al.
patent: 2007/0021430 (2007-01-01), Chen et al.
patent: 2007/0093501 (2007-04-01), Kubo et al.
patent: 2007/0179126 (2007-08-01), Casellas et al.
patent: 2007/0191340 (2007-08-01), Zindell et al.
patent: 2007/0213311 (2007-09-01), Li
patent: 2008/0039464 (2008-02-01), Berry et al.
patent: 2008/0064690 (2008-03-01), Atkinson et al.
patent: 2008/0081822 (2008-04-01), Berry et al.
patent: 2009/0163545 (2009-06-01), Goldfarb
patent: 2009/0275611 (2009-11-01), Riether et al.
patent: 2010/0009964 (2010-01-01), Berry et al.
patent: 2010/0029644 (2010-02-01), Riether et al.
patent: 2010/0076029 (2010-03-01), Bartolozzi et al.
patent: 2010/0081644 (2010-04-01), Bartolozzi et al.
patent: 312963 (1956-03-01), None
patent: 1080563 (1957-12-01), None
patent: 0628555 (1994-12-01), None
patent: 0929519 (1999-07-01), None
patent: 0970046 (2000-01-01), None
patent: 1790641 (2007-05-01), None
patent: 2866885 (2005-09-01), None
patent: 2872813 (2006-01-01), None
patent: 853799 (1960-11-01), None
patent: 884258 (1961-12-01), None
patent: 61-027905 (1986-02-01), None
patent: 61-027955 (1986-02-01), None
patent: 61027905 (1986-02-01), None
patent: 61126071 (1986-06-01), None
patent: 2003155285 (2003-05-01), None
patent: 9405628 (1994-03-01), None
patent: 9407607 (1994-04-01), None
patent: 9407607 (1994-04-01), None
patent: WO 96/26925 (1996-09-01), None
patent: 9712683 (1997-04-01), None
patent: 9712687 (1997-04-01), None
patent: 9712687 (1997-04-01), None
patent: 9720590 (1997-06-01), None
patent: 9746556 (1997-12-01), None
patent: 9808295 (1998-02-01), None
patent: 9813340 (1998-04-01), None
patent: 9838163 (1998-09-01), None
patent: 0100573 (2001-01-01), None
patent: 0129007 (2001-04-01), None
patent: 0164651 (2001-09-01), None
patent: 02051806 (2002-07-01), None
patent: 02062750 (2002-08-01), None
patent: 03037274 (2003-05-01), None
patent: 03055482 (2003-07-01), None
patent: 03000807 (2003-12-01), None
patent: 04000807 (2003-12-01), None
patent: 2004014825 (2004-02-01), None
patent: 2004018433 (2004-03-01), None
patent: 2004029027 (2004-04-01), None
patent: 2004/050643 (2004-06-01), None
patent: 2004050643 (2004-06-01), None
patent: 2004/060882 (2004-07-01), None
patent: 2004099200 (2004-11-01), None
patent: 2004099205 (2004-11-01), None
patent: 2005027837 (2005-03-01), None
patent: 2005/040355 (2005-05-01), None
patent: 2005040355 (2005-05-01), None
patent: 2005/085227 (2005-09-01), None
patent: 2006012227 (2006-02-01), None
patent: 2006060461 (2006-06-01), None
patent: 2006080040 (2006-08-01), None
patent: 2006095159 (2006-09-01), None
patent: 2006100502 (2006-09-01), None
patent: 2006117461 (2006-11-01), None
patent: 2007020502 (2007-02-01), None
patent: 2007054770 (2007-05-01), None
patent: 2007070760 (2007-06-01), None
patent: 2007070760 (2007-06-01), None
patent: 2007080382 (2007-07-01), None
patent: 2007-102059 (2007-09-01), None
patent: 2008023159 (2008-02-01), None
patent: 2008048914 (2008-04-01), None
patent: 2008064054 (2008-05-01), None
patent: 2008098025 (2008-08-01), None
patent: 2008104994 (2008-09-01), None
patent: 2009055357 (2009-04-01), None
patent: 2009061652 (2009-05-01), None
patent: 2009077533 (2009-06-01), None
patent: 2009105509 (2009-08-01), None
patent: 2009140089 (2009-11-01), None
patent: 2010005782 (2010-01-01), None
patent: 2010036630 (2010-04-01), None
patent: 2010036631 (2010-04-01), None
Derwent Abstract of JP 61-027955, Feb. 7, 1986.
Derwent Abstract of JP 61-027905, Feb. 7, 1986.
I. E. Marx, et al., “Discovery of a-amidosulfones as potent and selective agonists of CB2: Synthesis, SAR, and pharmacokinetic properties”. Bioorganic and Medicinal Chemistry Letters, 2008. In press, accepted manuscript.
ISR PCT/US2007/078341.
ISR PCT/US2007/074076.
Robert J. Watson, et al., “An enantioselective synthesis of sulphonamide hydroxamic acids as matrix metalloproteinase inhibitors”, Pergamon, Tetrahedron Letters 43 (2002) 683-685.
Monika Ermann, et al., “Arylsulfonamide CB2 receptor agonists: SAR and optimization of CB2 selectivity”, Bioorganic and Medicinal Chemistry Letters 18 (2008) 1725-1729.
Keith A. Sharkey, et al., “CB2 cannabinoid receptors: new vistas”, The first International Conference devoted to studies of the CB2 cannabinoid receptor. Banff, Alberta, Canada, May 31-Jun. 3, 2007.
Monika Ermann, et al., “Discovery of a novel class of CB2 receptor agonists”. Presented at the 14thSCI-RSC Medicinal Chemistry Symposium, Churchill College, Cambridge, UK, Sep. 23-26, 2007.
Monika Ermann, et al., “Discovery of a novel class of CB2 receptor agonists”. Presented at the Cambridge Healthcare Institute's 15th International Molecular Medicine Tri-Conference, Moscone Convention Center, San Francisco, CA, USA. Mar. 25-28, 2008.
Julius Troeger, et al., “Regarding sulfonated Butyric Acids”. From the Laboratory for Pharmaceutical and Synthetic Chemistry of the Braunschweig Institute of Technology. Journal of Practical Chemistry, 1899, vol. 59, p. 320.
Renee Zindell, et al., “Discovery of a novel class of CB2 agonists”. General Poster Session. The 235thACS National Meeting, New Orleans, LA, USA. Apr. 6-10, 2008.
A.V. Anisimov, et al., “Synthesis of Sulfonyl and Sulfenyl Derivatives of Pyridine and 1,2,4-Triazole”. Russian Journal of Organic Chemistry, 2006, vol. 42, No. 6, pp. 918-921.
Graham J. Atwell, et al., “Relationships between Structure and Kinetics of Cyclization of 2-Aminoaryl Amides: Potential Prodrugs of Cyclization-Activitated Aromatic Mustards”., J. Med. Chem, 1994, 37, 371-380.
N. G. Clark, et al., “The Fungicidal Activity of Substituted Acetanilides and Related Compounds”. vol. 55, p. 839-851.
Soad A. M. El-Hawash, et al., “Synthesis and invitro-Anticancer and Antimicrobial Evaluation of Some Novel Quinoxalines Derived from 3-Phenylquinoxaline-2(1H)-thione”. Arch. Pharm. Chem. Life Sci, 2006, 339, p. 437-447.
Wilfrid J. Evans, et al., “A Rearrangement of Carbamyl-sulphones and -sulphides”. p. 329-331
Berry Angela
Blumire Nigel
Cirillo Pier Francesco
Ermann Monika
Hickey Eugene Richard
Boehringer Ingelheim International GmbH
Bottino Anthony P.
Morris Michael P.
Powers Fiona T
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