Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-12-06
1994-11-22
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514382, 514462, 548237, 548252, 549236, 549264, 549345, A61K 3142, A61K 3141, C07D30794
Patent
active
053669860
ABSTRACT:
The present invention is directed to compounds which suppress immune responses and/or selectively inhibit complement. These compounds contain an aromatic ring and are substituted dihydrobenzofurans, spirobenzofuran-2(3H)-cycloalkanes, and their open chain intermediates. The compounds of the present invention, and the phamaceutically acceptable salts thereof, interrupt the proteolytic processing of C5 to bioactive components, exhibit immunosuppressive activites, and have therapeutic utility in the amelioration of disease and disorders mediated by complement and/or immune activity.
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Bradbury Barton J.
Ip Stephen H.
Kaufman Teodoro S.
Lee Chew
Marsh, Jr. Henry C.
Ivy C. Warren
Owens A. A.
T Cell Sciences, Inc.
The University of Mississippi
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