Compounds which inhibit complement and/or suppress immune activi

Details Compounds which inhibit complement and/or suppress immune activi Compounds which inhibit complement and/or suppress immune activi

1988-04-15

1992-12-22

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514825, 549345, A61K 3134, C07D30794

Patent

active

051734990

ABSTRACT:
The present invention is directed to compounds which suppress immune responses and/or selectively inhibit complement. These compounds contain an aromatic ring and are substituted dihydrobenzofurans, spirobenzofuran-2(3H)-cycloalkanes, and their open chain intermediates. The compounds of the present invention, and the pharmaceutically acceptable salts thereof, interrupt the proteolytic processing of C5 to bioactive components, exhibit immunosuppressive activities, and have therapeutic utility in the amelioration of disease and disorders mediated by complement and/or immune activity.

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