Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Reexamination Certificate
2007-02-27
2007-02-27
Kumar, Shailendra (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
C562S444000, C562S445000, C562S448000, C514S563000, C514S616000
Reexamination Certificate
active
10515459
ABSTRACT:
The invention relates to compounds having formula (I), which can block the response to chemical substances or thermal stimuli or mediators of inflammation of nociceptors, a production method thereof and compositions containing same. According to the invention, Ar is a phenyl group substituted with one or more halogen groups; R1is amino, hydroxyl or thiol, all of which may or may not be substituted with formula (II) or with aliphatic or cyclic groups; R2is H or an alkyl, aryl, aralkyl or acyl group or formula (III); R3is H or formula (IV); R4and R6are H or an aliphatic or cyclic group; R5is H or formula (V); R7is H or an aliphatic or cyclic group; Z is amino, hydroxyl or thiol, all of which may or may not be substituted with aliphatic or cyclic groups; W is a linkage or formula (VI); X is a linkage or formula (VII); Y is amino which may or may not be substituted with formula (VIII) or an alkyl, aryl, aralkyl or acyl group; m, q and s can vary between 1 and 9 and n and p can vary between 1 and 10
REFERENCES:
patent: WO 02/30956 (2002-04-01), None
Carolina Garcia-Martinez, et al. “Attenuation of thermal nociception and hyperalgesia by VR1 blockers”PNAS, vol. 99, No. 4, Feb. 19, 2002, pp. 2374-2379.
Jacqueline A. Gibbons, et al. “Pharmacologic Characterization of CHIR 2279, an N-Substituted Glycine Peptoid wtih High-Affinity Binding for α1-Adrenoceptors”,Journal of Pharmacology and Experimental Therapeutics, vol. 277, No. 2, 1996, pp. 885-899.
John A. W. Kruijtzer, et al. “Solid-Phase Syntheses of Peptoids using Fmoc-Protected N-Substituted Glycines: The Syntheses of (Retro) Peptoids of Leu-Enkephalin and Substance P”Chem. Eur. J. 1998, No. 8, pp. 1570-1580.
Humet, M., et al., “A Positional Scanning Combinatorial Library of Peptoids As a Source of Biological Active Molecules: Identification of Antimicrobials”,J. Comb. Chem., 5:597-605 (2003).
Carvajal Asia Fernández
Martínez Carlos Belmonte
Martínez Carolina Garcia
Montiel Antonio Ferrer
Nest Wim Van Den
Diverdrugs, S.L.
Kumar Shailendra
Ostrolenk Faber Gerb & Soffen, LLP
LandOfFree
Compounds which can block the response to chemical... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compounds which can block the response to chemical..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds which can block the response to chemical... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3872810