Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2003-12-30
2010-06-29
Navarro, Mark (Department: 1645)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C530S300000, C424S185100, C435S975000
Reexamination Certificate
active
07745580
ABSTRACT:
The present invention relates to nucleic acid molecules related to the var2csa gene family as well as amino acid sequences encoded by such nucleic acid molecules with respect to their role in mediating adhesion of infected red blood cells to chondroitin sulphate A (CSA) in the placenta which is characteristic for the pathogenesis of pregnancy associated malaria (PAM). Accordingly, The invention provides the use compounds that are related to VAR2CSA polypeptides var2csa nucleic acid molecules as medicaments, as well as it provides pharmaceutical compositions, in particular immunological compositions and vaccines, hereunder nucleotide-based vaccines comprising these compounds. In addition, the invention provides the use of the compounds mentioned for the manufacture of compositions, such as immunogenic compositions. Other aspects of the invention relates to methods of treatment and prevention of pregnancy associated malaria wherein these methods are based on the nucleic acid molecules and polypeptides the invention. As these compounds can also be used as biotechnological tools the invention provides in vitro diagnostic methods and kits comprising reagents and IgGs/antibodies designated to the use in such methods. The invention also relates to methods of identifying agents capable of modulating the VAR2CSA dependent adhesion to CSA and agent capable of interacting with VAR2CSA. Finally, a method for identifying polypeptides, which will induce a specific IgG/antibody response upon administration to a subject is provided by the invention.
REFERENCES:
patent: WO 00/25728 (2000-05-01), None
patent: WO 01/16326 (2001-03-01), None
patent: WO0116326 (2001-03-01), None
patent: WO0116326 (2001-03-01), None
Michal Fried et al., “Maternal antibodies block malaria”, Nature, vol. 395, Oct. 29, 1998, pp. 851-852.
Malcolm J. Gardner et al., “Genome sequence of the human malaria parasitePlasmodium falciparum”, Nature vol. 419, 2002, pp. 498-511.
Thomas Lavstsen et al., “Sub-grouping ofPlasmodium falciparum3D7 var genes based on sequence analysis of coding and non-coding regions”, Malaria Journal, 2003,2, pp. 1-14.
Iona O'Neil-Dunne et al., “Gravidity-Dependent Production of Antibodies That Inhibit Binding ofPlasmodium falciparum-Infected Erythorocytes to Placental Chondroitin Sulfate Proteoglycan during Pregnancy”, Infection and Immunity, Dec. 2001, pp. 7487-7492.
Bridget A. Robinson et al., “Widespread functional specialization ofPlasmodium falciparumerythrocyte membrane protein 1 family members to bind CD36 analysed across a parasite genome”, Molecular Microbiology (2003) 47(5), 1265-1278.
C.E. Shulman et al., “Malaria in pregnancy: adverse effects on haemoglobin levels and birthweight in primigravidae and multigravidae”, Tropical Medicine and International Health, vol. 6, No. 10, pp. 770-778, Oct. 2001.
Joseph D. Smith et al., “Classification of adhesive domains in thePlasmodium falciparumErythrocyte Membrane Protein 1 family”, Molecular and Biochemical Parasitology 110 (2000) 293-310.
Joseph D. Smith et al., “Switches in Expression ofPlasmodium falcimparumvar Genes Correlate with Changes in Antigenic and Cytoadherent Phenotypes of Infected Erythrocytes”, Cell, vol. 82, 101-110, Jul. 14, 1995.
Trine Staalsoe et al., “Detection of Antibodies to Variant Antigens onPlasmodium falciparum-Infected Erythrocytes by Flow Cytometry”, Cytometry, 35:329-336 (1999).
Mats Wahlgren et al., “Waves of Malarial Var-Iations”, Cell, vol. 96, pp. 603-606, Mar. 5, 1999.
Database EMBL ′Online!, Oct. 3, 2002, M.J. Gardner et al., “Plasmodium falciparum3D7 chromosome 12 section 1 of 9 of the complete sequence”.
Database EMBL ′Online! Jul. 20, 2002, K. Tang et al., PfESToab46901.ylPlasmodium falciparum3D7 asexual cDNAPlasmodium falciparumcDNA 5′ similar to TR:Q26030 Q26030 Variant Surface Protein;, mRNA sequence.
Ali Salanti et al., “A sub-family of common and highly conservedPlasmodium falciparumvar genes”, Molecular & Biochemical Parasitology vol. 122, No. 1, Jun. 2002, pp. 111-115.
Patrick Duffy et al., “Variant proteins on the surface of malaria-infected erythrocytes: Developing vaccines”, Trends in Parasitology, vol. 17, No. 8, Aug. 2001, pp. 354-356.
Pierre A. Buffet et al., “Plasmodium falciparumdomain mediating adhesion to chondroitin sulfate A: A receptor for human placental infection”, Proceedings of the National Academy of Sciences of USA National Academy of Science, Washington, US, vol. 96, No. 22, Oct. 26, 1999, pp. 12743-12748.
C. H. Ricke et al., “Plasma antibodies from malaria-exposed pregnant women recognize variant surface antigens onPlasmodium falciparum-infected erythrocytes in a parity-dependent manner and block parasite adhesion to chondroitin sulfate A”, Journal of Immunology (Baltimore MD: 1950), US, Sep. 15, 2000, vol. 165, No. 6, pp. 3309-3316.
Trine Staalsoe et al., “Acquisition and decay of antibodies to pregnancy-associated variant antigens on the surface ofPlasmodium falciparum: Infected erythrocytes that protect against placental parasitemia”, Journal of Infectious Diseases, vol. 184, No. 5, 2001, pp. 618-626.
Ali Salanti et al., “Selective upregulation of a single distinctly structured var gene in chondroitin sulphate A-adhereingPlasmodium falciparuminvolved in pregnancy-associated malaria”, Molecular Microbiology, vol. 49, No. 1, Jul. 20, 2003, pp. 179-191.
Dahlbäck Madelaine
Hviid Lars
Jensen Anja Tatiana Ramstedt
Lavstsen Thomas
Salanti Ali
Bent Stephen A.
Foley & Lardner LLP
Kobenhavns Universitet
Navarro Mark
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