Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-05-18
1997-03-25
Haley, Jacqueline
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514363, 514364, 514381, 514521, 548127, 548128, 548131, 548134, 548136, 548143, 548252, A61K 31275, C07C25550
Patent
active
056145403
ABSTRACT:
Novel compounds of Formula (I) ##STR1## where X.sub.4 is a substituted cyclohexane or cyclohexane group and the other radicals are defined herein. These compounds inhibit the production of Tumor Necrosis Factor and are useful in the treatment of disease states mediated or exacerbated by TNF production. The compounds of the present invention are also useful in the mediation or inhibition of enzymatic or catalytic activity of phosphodiesterase IV and are therefore useful in the treatment of disease states in need of mediation or inhibition thereof.
REFERENCES:
patent: 3862239 (1975-01-01), Karmas
patent: 4795757 (1989-01-01), Regan et al.
Chemical Abstracts, vol. 90, No. 11, Mar. 1979, abstract 86895p.
Haley Jacqueline
Kanagy James M.
Lentz Edward T.
SmithKline Beecham Corporation
Venetianer Stephen
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