Compounds useful for modulating abnormal cell proliferation

Details Compounds useful for modulating abnormal cell proliferation Compounds useful for modulating abnormal cell proliferation

2007-03-19

2008-08-05

Kumar, Shailendra (Department: 1621)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

C514S252010, C514S256000, C514S307000, C514S311000, C514S357000, C514S396000, C514S412000, C514S438000, C514S461000

Reexamination Certificate

active

07407989

ABSTRACT:
There is described compounds of Formula I, and salts, solvates and hydrates thereof:wherein: R1, R2and R3are each independently selected from OH, C1-6alkyl, OC1-6alkyl, OC(O)C1-6alkyl, C(O)OC1-6alkyl, NH2, NH—C1-6alkyl, N(C1-6alkyl)(C1-6alkyl), C(O)NHC1-6alkyl, C(O)N(C1-6alkyl)(C1-6alkyl), SH, SC1-6alkyl, NO2, CF3, OCF3and halogen; and Ar is an aromatic or heteroaromatic group chosen from benzene, naphthalene, quinoline, isoquinoline, indole, pyridine, pyrasine, pyrimidine, imidazole, furan and thiophene, unsubstituted or substituted with 1-4 substituents independently selected from OH, C1-6alkyl, C1-6alkoxy, C1-3alkylenedioxy, NH2, NH—C1-6alkyl, N(C1-6alkyl)(C1-6alkyl), SH, S—C1-6alkyl, NO2, CF3, OCF3and halogen. The compounds of Formula I are useful: in therapeutic methods and compositions for modulating cell proliferation, in diagnostic assays and as research tools.

REFERENCES:
patent: 4673684 (1987-06-01), Wakabayashi et al.
patent: 7202383 (2007-04-01), Roifman et al.
patent: WO 01/79158 (2001-10-01), None
patent: WO 02/26696 (2002-04-01), None
patent: WO 03/062190 (2003-07-01), None
Rolfman, C.M. et al., “Tyrenes: synthesis of new antiproliferative compounds with an extended conjugation,” Bioorganic and Medicinal Chemistry, 12(2004), 3019-3026.
International Search Report for PCT/CA2005/001395, 2005.

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