Compounds useful for modulating abnormal cell proliferation

Details Compounds useful for modulating abnormal cell proliferation Compounds useful for modulating abnormal cell proliferation

2007-04-10

2007-04-10

Kumar, Shailendra (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C514S617000, C514S307000, C514S311000, C514S357000, C514S412000, C514S396000, C514S256000, C514S252100, C514S461000, C514S438000, C546S139000, C546S176000, C546S329000, C548S335500, C548S503000, C544S242000, C544S358000, C549S074000, C549S491000

Reexamination Certificate

active

10940010

ABSTRACT:
There is described compounds of Formula I, and salts, solvates and hydrates thereof:wherein: R1, R2and R3are each independently selected from OH, C1-6alkyl, OC1-6alkyl, OC(O)C1-6alkyl, C(O)OC1-6alkyl, NH2, NH—C1-6alkyl, N(C1-6alkyl)(C1-6alkyl), C(O)NHC1-6alkyl, C(O)N(C1-6alkyl)(C1-6alkyl), SH, SC1-6alkyl, NO2, CF3, OCF3and halogen; and Ar is an aromatic or heteroaromatic group chosen from benzene, naphthalene, quinoline, isoquinoline, indole, pyridine, pyrasine, pyrimidine, imidazole, furan and thiophene, unsubstituted or substituted with 1–4 substituents independently selected from OH, C1-6alkyl, C1-6alkoxy, C1-3alkylenedioxy, NH2, NH—C1-6alkyl, N(C1-6alkyl)(C1-6)(C1-6alkyl), SH, S—C1-6alkyl, NO2, CF3, OCF3and halogen. The compounds of Formula I are useful: in therapeutic methods and compositions for modulating cell proliferation, in diagnostic assays and as research tools.

REFERENCES:
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patent: WO 01/79158 (2001-10-01), None
patent: WO 02/26696 (2002-04-01), None
patent: WO 03/062190 (2003-07-01), None
Carter et al., Chemotherapy of Cancer, second edition, John Wiley & Sons, N.Y., N.Y., 1981, pp. 362-365.
Roifman, C.M. et al., “Tyrenes: synthesis of new antiproliferative compounds with an extended conjugation,” Bioorganic and Medicinal Chemistry, 12(2004), 3019-3026.
International Search Report for PCT/CA2005/001395, 2005.

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