Compounds useful for inhibition of farnesyl protein transferase

Details Compounds useful for inhibition of farnesyl protein transferase Compounds useful for inhibition of farnesyl protein transferase

1997-09-11

2000-02-29

Huang, Evelyn Mei

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142282, 5142328, 544 582, 544126, 546 93, A61K 31445, A61K 3154, A61K 31535, C07D40114, C07D41114, C07D41314

Patent

active

060309822

ABSTRACT:
Novel compounds of the formula: ##STR1## are disclosed. Compounds of Formula 1.0 are represented by the compounds of formulas: ##STR2## wherein R.sup.1, R.sup.3 and R.sup.4 are each independently selected from halo. Also disclosed are methods of inhibiting farnesyl protein transferase and the growth of abnormal cells, such as tumor cells.

REFERENCES:
patent: 4826853 (1989-05-01), Piwinski et al.
patent: 5089496 (1992-02-01), Piwinski et al.
patent: 5151423 (1992-09-01), Piwinski et al.
patent: 5393890 (1995-02-01), Syoji et al.
patent: 5661152 (1997-08-01), Bishop et al.
patent: 5672611 (1997-09-01), Doll et al.
patent: 5684013 (1997-11-01), Afonso et al.
patent: 5696121 (1997-12-01), Bishop et al.
patent: 5700806 (1997-12-01), Doll
patent: 5703090 (1997-12-01), Afonso et al.
patent: 5712280 (1998-01-01), Doll et al.
patent: 5714609 (1998-02-01), Bishop et al.
patent: 5719148 (1998-02-01), Bishop
patent: 5721236 (1998-02-01), Bishop et al.
patent: 5728703 (1998-03-01), Bishop et al.
Khosravi-far R et al. Cell Growth & Differentiation. 3, 461-9, Jul. 1992.
Buss, J.E. et al. "Farnesyl transferase inhibitors the successes and surprises of a new class of potential cancer chemotherapeutics" Chem. Biol., vol. 2, Dec. 1995, pp. 787-791.
Njoroge, F.G. et al., "Discovery of a novel Nonpeptide Tricyclic Inhibitors of RAS Farnesyl Transferase" Bioorg. & Med. Chem. Lett., vol. 5, No. 1, 1997, pp. 101-113.
Bishop et al., The Journal of Biological Chemistry, vol. 270, No. 15, pp.30611-30618 (1995).
Njoroge et al., Bioorganic & Medicinal Chemistry Letters, vol. 6, No.24, pp.2977-2982 (1996).

Affiliated with

Also associated with

Rating

Compounds useful for inhibition of farnesyl protein transferase does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compounds useful for inhibition of farnesyl protein transferase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds useful for inhibition of farnesyl protein transferase will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-683333