Compounds useful for concurrently activating glucocorticoid-indu

Details Compounds useful for concurrently activating glucocorticoid-indu Compounds useful for concurrently activating glucocorticoid-indu

1995-05-10

1998-06-16

Jarvis, William R.A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514188, 514181, 514177, 514178, 514179, 514172, 514174, 514175, A61K 3158, A61K 3156, A61K 31585

Patent

active

057671133

ABSTRACT:
In accordance with the present invention, it has been discovered that certain synthetic steroid compounds are capable of inhibiting the efflux pump which is believed to be responsible for multidrug resistance, while at the same time activating glucocorticoid-induced response. Thus, chemotherapy of glucocorticoid sensitive tumors can be enhanced by use of a compound having the dual ability to activate glucocorticoid-induced response and facilitate the accumulation of drug at the target site, with reduced or eliminated competition by the drug efflux system.

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