Compounds useful as reversible inhibitors of cysteine proteases

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C544S092000

Reexamination Certificate

active

07056915

ABSTRACT:
Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (I), (II), (Ia) and (Ib) further defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds

REFERENCES:
patent: 4734425 (1988-03-01), Nakane et al.
patent: 4749715 (1988-06-01), Hall
patent: 4797202 (1989-01-01), Klimpel et al.
patent: 4957932 (1990-09-01), Young et al.
patent: 4962117 (1990-10-01), Young et al.
patent: 5196291 (1993-03-01), Okada et al.
patent: 5218123 (1993-06-01), Horwell et al.
patent: 5250732 (1993-10-01), Kogan et al.
patent: 5328803 (1994-07-01), Fujikura et al.
patent: 5346907 (1994-09-01), Kerwin et al.
patent: 5461176 (1995-10-01), Sun et al.
patent: 5504109 (1996-04-01), Seitz et al.
patent: 5514778 (1996-05-01), Hammond et al.
patent: 5633248 (1997-05-01), Kato et al.
patent: 5691368 (1997-11-01), Peet et al.
patent: 5710129 (1998-01-01), Lynch et al.
patent: 5744451 (1998-04-01), Allen et al.
patent: 5756528 (1998-05-01), Anthony et al.
patent: 5847135 (1998-12-01), Bemis et al.
patent: 5872122 (1999-02-01), Bovy et al.
patent: 5976858 (1999-11-01), Palmer et al.
patent: 6420364 (2002-07-01), Emmanuel et al.
patent: 3827727 (1990-02-01), None
patent: 4343528 (1993-12-01), None
patent: 4225487 (1994-02-01), None
patent: 4303145 (1994-08-01), None
patent: 4321897 (1995-01-01), None
patent: 19609955 (1997-09-01), None
patent: 19653647 (1998-06-01), None
patent: 0 115 472 (1984-08-01), None
patent: 0294668 (1988-12-01), None
patent: 0308885 (1989-03-01), None
patent: 0314060 (1989-05-01), None
patent: 0318083 (1989-05-01), None
patent: 0336356 (1989-10-01), None
patent: 0374098 (1990-06-01), None
patent: 0398072 (1990-11-01), None
patent: 0483667 (1992-05-01), None
patent: 0506008 (1992-09-01), None
patent: 0529737 (1993-03-01), None
patent: 0533244 (1993-03-01), None
patent: 0542463 (1993-05-01), None
patent: 0547699 (1993-06-01), None
patent: 587110 (1994-03-01), None
patent: 0 604 182 (1994-06-01), None
patent: 0611756 (1994-08-01), None
patent: 0611756 (1994-08-01), None
patent: 0644198 (1995-03-01), None
patent: 0649057 (1995-04-01), None
patent: 0 652 229 (1995-05-01), None
patent: 0672654 (1995-09-01), None
patent: 805147 (1997-11-01), None
patent: 810206 (1997-12-01), None
patent: 0 838 471 (1998-04-01), None
patent: 844248 (1998-05-01), None
patent: 844248 (1998-05-01), None
patent: 846464 (1998-06-01), None
patent: 846464 (1998-06-01), None
patent: 897908 (1999-02-01), None
patent: 2694006 (1994-01-01), None
patent: 662788 (1965-08-01), None
patent: 68010619 (1968-05-01), None
patent: 6358346 (1988-03-01), None
patent: 63301868 (1988-12-01), None
patent: 3002872 (1991-01-01), None
patent: 6003787 (1994-01-01), None
patent: 6051451 (1994-02-01), None
patent: 6145173 (1994-05-01), None
patent: 6293772 (1994-10-01), None
patent: 6340643 (1994-12-01), None
patent: 7-101959 (1995-04-01), None
patent: 7285931 (1995-10-01), None
patent: 8248579 (1996-09-01), None
patent: 11100373 (1999-04-01), None
patent: WO 8808717 (1988-11-01), None
patent: WO 89/10920 (1989-11-01), None
patent: WO 90/13561 (1990-11-01), None
patent: WO 91/19733 (1991-12-01), None
patent: WO 92/01675 (1992-02-01), None
patent: WO 92/14465 (1992-09-01), None
patent: WO 92/17453 (1992-10-01), None
patent: WO 92/21361 (1992-12-01), None
patent: WO 92/22570 (1992-12-01), None
patent: WO 93/05444 (1993-03-01), None
patent: WO 93/12075 (1993-06-01), None
patent: WO 93/14069 (1993-07-01), None
patent: WO 94/00435 (1994-01-01), None
patent: WO 94/06757 (1994-03-01), None
patent: WO 94/07841 (1994-04-01), None
patent: WO 94/21657 (1994-09-01), None
patent: WO 94/22911 (1994-10-01), None
patent: WO 94/25432 (1994-10-01), None
patent: WO 95/01344 (1995-01-01), None
patent: WO 95/06029 (1995-03-01), None
patent: WO 95/09838 (1995-04-01), None
patent: WO 95/12611 (1995-05-01), None
patent: WO 95/15749 (1995-06-01), None
patent: WO 95/23222 (1995-08-01), None
patent: WO 95/24382 (1995-09-01), None
patent: WO 95/29899 (1995-11-01), None
patent: WO 95/33728 (1995-12-01), None
patent: WO 95/35308 (1995-12-01), None
patent: WO 96/07638 (1996-03-01), None
patent: WO 96/10559 (1996-04-01), None
patent: WO 96/12499 (1996-05-01), None
patent: WO 96/13502 (1996-05-01), None
patent: WO 96/16940 (1996-06-01), None
patent: WO 96/20725 (1996-07-01), None
patent: WO 96/20949 (1996-07-01), None
patent: WO 96/22970 (1996-08-01), None
patent: WO 96/26194 (1996-08-01), None
patent: WO 96/30353 (1996-10-01), None
patent: WO 96/33168 (1996-10-01), None
patent: WO 96/33170 (1996-10-01), None
patent: WO 96/33211 (1996-10-01), None
patent: WO 96/37499 (1996-11-01), None
patent: WO 96/39137 (1996-12-01), None
patent: WO 96/39384 (1996-12-01), None
patent: WO 96/40647 (1996-12-01), None
patent: WO 96/40737 (1996-12-01), None
patent: WO 96/40741 (1996-12-01), None
patent: WO 96/40742 (1996-12-01), None
patent: WO 96/40744 (1996-12-01), None
patent: WO 96/40751 (1996-12-01), None
patent: WO 96/40752 (1996-12-01), None
patent: WO 96/40753 (1996-12-01), None
patent: WO 97/01275 (1997-01-01), None
patent: WO 97/10219 (1997-03-01), None
patent: WO 97/19908 (1997-06-01), None
patent: WO 97/22618 (1997-06-01), None
patent: WO 97/22619 (1997-06-01), None
patent: WO 97/22621 (1997-06-01), None
patent: WO 97/22621 (1997-06-01), None
patent: WO 97/24343 (1997-07-01), None
patent: WO 97/26246 (1997-07-01), None
patent: WO 97/27200 (1997-07-01), None
patent: WO 97/27220 (1997-07-01), None
patent: WO 97/31016 (1997-08-01), None
patent: WO 97/31016 (1997-08-01), None
patent: WO 97/45016 (1997-12-01), None
patent: WO 97/46518 (1997-12-01), None
patent: WO 98/04278 (1998-02-01), None
patent: WO 98/04518 (1998-02-01), None
patent: WO 98/14450 (1998-04-01), None
patent: WO 98/17679 (1998-04-01), None
patent: WO 98/21199 (1998-05-01), None
patent: WO 98/21199 (1998-05-01), None
patent: WO 98/22433 (1998-05-01), None
patent: WO 98/25617 (1998-06-01), None
patent: WO 98/26654 (1998-06-01), None
patent: WO 98/26654 (1998-06-01), None
patent: WO 98/28269 (1998-07-01), None
patent: WO 98/38177 (1998-09-01), None
patent: WO 98/47863 (1998-10-01), None
patent: WO 98/52558 (1998-11-01), None
patent: WO 98/52559 (1998-11-01), None
patent: WO 98/52941 (1998-11-01), None
patent: WO 98/57937 (1998-12-01), None
patent: WO 98/57937 (1998-12-01), None
patent: WO 98/57951 (1998-12-01), None
patent: WO 99/23063 (1999-05-01), None
patent: WO 99/24460 (1999-05-01), None
patent: WO 99/32106 (1999-07-01), None
patent: WO 99/32455 (1999-07-01), None
patent: WO 99/56765 (1999-11-01), None
patent: WO 00/51998 (2000-08-01), None
patent: WO 00/55125 (2000-09-01), None
patent: WO 00/55126 (2000-09-01), None
patent: 950892 (1995-02-01), None
Bence Ashboth, et al; Mechanism of Action of Cysteine Proteinases: Oxyanion Binding Site Is Not Essential in the Hydrolysis of Specific Substrates, BioChemistry 1985, 24, 606-609.
Robert P. Hanzlik, et al; Reversible Covalent Binding of Peptide Nitriles to Papain; Biochimica et Biophysica Acta, 1035 (1990) 62-70 Elsevier.
Tzyy-Chyau Liang, et al; Inhibition of Papain by Nitriles: Mechanistic Studies Using NMR and Kinetic Measurements, Archives of Biochemistry and Biophysics vol. 252, No. 2, Feb. 1, pp. 626-634, 1987.
David J. Buttle, et al; Affinity Purification of the Novel Cysteine Proteinase Papaya Proteinase IV, and Papain from Papaya Latex, Biochem J. (1989) 261, 469-476.
Paul R. Carey, et al; Identity of acyl group conformation in the active sites of papain and cathepsin B by resonance Raman spectroscopy, J. Biol. Chem 1984, 259(23), 14357-14360—XP002129209 from Chem. Abstract 102:2545e.
Siming Liu, et al ; The Contribution of intermolecular hydrogen bonding to the kinetic specificity of papain, Biochim. Biophys. Acta 1993, 1158(3), 264-72—XP-002129210 from Chem Abstract 120:292661a.
Eric Dufour, et al; Engineering Nitrile Hydratase Activity into a Cysteine Protease by a Single Mutation, Biochemistry 1995, 34, 16382-16388,—XP 002129204.
Joseph B. Moon, et al; Reversible Covalent Inhibition of Papain by a Peptide Nitrile, C NME Evid

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Compounds useful as reversible inhibitors of cysteine proteases does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compounds useful as reversible inhibitors of cysteine proteases, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds useful as reversible inhibitors of cysteine proteases will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3637209

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.